In vivo Antioxidant Potential of Biogenic Silver Nanoparticles Synthesized from Psidium guajava L

Excessive utilization of nanoparticles renders it necessary to produce safer and more secure nanoparticles while preserving their efficacy. In this study, Psidium guajava L. pulp extract-mediated silver nanoparticles (AgNPs) were synthesized, characterized, and further evaluated regarding their anti...

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Bibliographic Details
Published in:Nano biomedicine and engineering 2023-07, Vol.15 (3), p.225-238
Main Authors: Yaqub, Atif, Rashid, Muhammad, Ditta, Sarwar Allah, Malkani, Naila, Ali, Nazish Mazhar, Yousaf, Muhammad Zubair, Haider, Arslan, Yousaf, Muhammad Jamil, Abdullah, Saman
Format: Article
Language:English
Subjects:
acute toxicity
catalase
nanotoxicity
oxidative stress
safer nanoparticles
silver nanoparticles (agnps)
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Summary:Excessive utilization of nanoparticles renders it necessary to produce safer and more secure nanoparticles while preserving their efficacy. In this study, Psidium guajava L. pulp extract-mediated silver nanoparticles (AgNPs) were synthesized, characterized, and further evaluated regarding their antioxidant potential. The green synthesized silver nanoparticles (G-AgNPs) showed a higher level of radical scavenging activity (RSA) (25.85%), hydrogen peroxide scavenging activity (34.34%), and ferric reducing power (0.28). The comparison of the control group (G1) with the various treatment groups (G2–G6) revealed that the levels of catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST) were significantly different (P < 0.05). The levels of blood urea, uric acid, blood urea nitrogen (BUN), serum glutamic pyruvic transaminase (SGTP), serum creatinine, serum glutamic-oxaloacetic transaminase (SGOT), alkaline phosphatase, total bilirubin, and serum electrolytes were also evaluated. The results of clinical biochemistry also strengthened our hypothesis that G-AgNPs are less toxic than C-AgNPs. Finally, the histopathology of liver, kidney, and intestinal tissues indicated that green-synthesized AgNPs are relatively safer.
ISSN:2150-5578
2150-5578
DOI:10.26599/NBE.2023.9290026