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Bone marrow metastasis from advanced gastric cancer complicated with disseminated intravascular coagulation: a highly aggressive but manageable disease subtype

[...]inflammatory markers, such as white blood cells (WBC) counts, neutrophil counts, neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP) level were increased in HAGC when effects of colony-stimulating factor and infection were excluded (Supplementary Table S3). [...]the ratio of pro-i...

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Published in:Cancer communications (London, England) England), 2022-04, Vol.42 (4), p.350-354
Main Authors: Zhai, Xiaohui, Wang, Caiqin, Li, Shanshan, Cao, Taiyuan, Du, Ge, Zhang, Yan, Chen, Dianke, Fan, Xinjuan, Huang, Yan, Hu, Ping, Zheng, Jian, Yang, Zuli, Lian, Lei, Peng, Junsheng, Lan, Ping, Xiao, Jian
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Language:English
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Summary:[...]inflammatory markers, such as white blood cells (WBC) counts, neutrophil counts, neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP) level were increased in HAGC when effects of colony-stimulating factor and infection were excluded (Supplementary Table S3). [...]the ratio of pro-inflammatory M1 and anti-inflammatory M2 was elevated in the HAGC tumor immune environment (TIME), indicating an inflammatory environment [ 6] (Figure 1A, Supplementary Figure S1). [...]RNA-seq results demonstrated inflammatory response and IL-6-JAK-STAT3 signaling activation in HAGC patients (Figure 1C, Supplementary Figure S2). [...]most of these patients only received BSC and did not undergo further examinations; thus, indicating that the incidence of DIC in HAGC could be higher than estimated.
ISSN:2523-3548
2523-3548
DOI:10.1002/cac2.12277