Innate Lymphoid Cells and Their Role in the Immune Response to Infections

Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells th...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2024-02, Vol.13 (4), p.335
Main Authors: Fol, Marek, Karpik, Wojciech, Zablotni, Agnieszka, Kulesza, Jakub, Kulesza, Ewelina, Godkowicz, Magdalena, Druszczynska, Magdalena
Format: Article
Language:English
Subjects:
Antigens
Cell Differentiation
Cytokines
Cytotoxicity
Effector cells
extracellular pathogens
Health aspects
Homeostasis
Immune response
Immunity, Innate
Immunological research
Infections
innate immune cells (ILC)
intracellular pathogens
Leukocytes
Lungs
Lymphocytes
Lymphoid cells
Metabolism
Pathogens
Tuberculosis
Tumor necrosis factor-TNF
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells that act as tissue-resident sentinels against infections. Numerous studies have elucidated the characteristics of ILC subgroups, but the mechanisms controlling protective or pathological responses to pathogens still need to be better understood. This review summarizes the functions of ILCs in the immunology of infections caused by different intracellular and extracellular pathogens and discusses their possible therapeutic potential.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells13040335