Retrospective analysis of negative cytology results correlated with a positive high-risk in the human papillomavirus result and subsequent results of patients over a period of three years

This research paper evaluates the efficacy of co-testing in precluding cervical cancer, with a particular focus on distinguishable outcomes of the human papillomavirus (HPV) vs. cytology tests. A retrospective review of 5948 patients, who tested positive for high-risk HPV but showed negative cytolog...

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Bibliographic Details
Published in:Polish journal of pathology 2024-01, Vol.75 (1), p.36-39
Main Authors: Piotrowski, Paweł Gerard, Jeleń, Michał Teodor
Format: Article
Language:English
Subjects:
Adult
Aged
cervical cancer
co-testing
cytology tests
Early Detection of Cancer - methods
efficacy
false-negative cytology
Female
high-risk hpv
hpv
Human Papillomavirus Viruses
Humans
Middle Aged
mrna-based hpv testing
Papillomavirus Infections - complications
Papillomavirus Infections - diagnosis
Papillomavirus Infections - virology
preventive care
retrospective review
Retrospective Studies
Uterine Cervical Dysplasia - diagnosis
Uterine Cervical Dysplasia - pathology
Uterine Cervical Dysplasia - virology
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
Vaginal Smears
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Summary:This research paper evaluates the efficacy of co-testing in precluding cervical cancer, with a particular focus on distinguishable outcomes of the human papillomavirus (HPV) vs. cytology tests. A retrospective review of 5948 patients, who tested positive for high-risk HPV but showed negative cytologic findings, revealed that 15.006% tested positive in subsequent screenings. A comparative analysis of various commercial HPV tests highlighted the precision of mRNA-based HPV testing by Aptima (Hologic) in reducing the likelihood of false-negative cytology. The paper challenges the conviction that a negative cytology alone suffices advocating for a condensed testing interval in instances of positive HPV outcomes, thereby facilitating earlier intervention and optimal preventive care. These findings unveil an exigency for reconsidering preventive strategies based on test outcomes.
ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2024.135828