Vitamin D Deficiency Is Associated with Increased Osteocalcin Levels in Acute Aortic Dissection: A Pilot Study on Elderly Patients

An imbalance between degradation and reconstruction of the aortic wall is one of the leading causes of acute aortic dissection (AAD). Vitamin D seems an intriguing molecule to explore in the field of AAD since it improves endothelial function and protects smooth muscle cells from inflammation-induce...

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Published in:Mediators of inflammation 2017-01, Vol.2017 (2017), p.1-8
Main Authors: Corsi Romanelli, Massimiliano M., Trimarchi, Santi, Lamont, John, Tacchini, Lorenza, Barassi, A., Dozio, Elena, Vianello, Elena, Marrocco-Trischitta, Massimiliano M.
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Aged patients
Alkaline Phosphatase - blood
Aneurysm, Dissecting - blood
Calcium - blood
Dissecting aneurysm
Female
Health aspects
Humans
Laboratories
Male
Measurement
Middle Aged
Osteocalcin - blood
Parathyroid Hormone - blood
Physiological aspects
Pilot Projects
Protein hormones
Studies
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin deficiency
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creator Corsi Romanelli, Massimiliano M.
Trimarchi, Santi
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Vianello, Elena
Marrocco-Trischitta, Massimiliano M.
description An imbalance between degradation and reconstruction of the aortic wall is one of the leading causes of acute aortic dissection (AAD). Vitamin D seems an intriguing molecule to explore in the field of AAD since it improves endothelial function and protects smooth muscle cells from inflammation-induced remodeling, calcification, and loss of function, all events which are strongly related to the aging process. We quantified 25-hydroxy vitamin D, calcium, parathormone, bone alkaline phosphatase, and osteocalcin levels in 24 elderly AAD patients to identify a potential pathological implication of these molecules in AAD. Median 25-hydroxy vitamin D (10.75 ng/mL, 25th–75th percentiles: 6.86–19.23 ng/mL) and calcium levels (8.70 mg/dL, 25th–75th percentiles: 7.30–8.80 mg/dL) suggested hypovitaminosis D and a moderate hypocalcemia. Thirty-eight percent of AAD patients had severe (
doi_str_mv 10.1155/2017/6412531
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Vitamin D seems an intriguing molecule to explore in the field of AAD since it improves endothelial function and protects smooth muscle cells from inflammation-induced remodeling, calcification, and loss of function, all events which are strongly related to the aging process. We quantified 25-hydroxy vitamin D, calcium, parathormone, bone alkaline phosphatase, and osteocalcin levels in 24 elderly AAD patients to identify a potential pathological implication of these molecules in AAD. Median 25-hydroxy vitamin D (10.75 ng/mL, 25th–75th percentiles: 6.86–19.23 ng/mL) and calcium levels (8.70 mg/dL, 25th–75th percentiles: 7.30–8.80 mg/dL) suggested hypovitaminosis D and a moderate hypocalcemia. Thirty-eight percent of AAD patients had severe (&lt;10 ng/mL), 38% moderate (10–20 ng/mL), and 24% mild 25-hydroxy vitamin D deficiency (20–30 ng/mL). A significant inverse correlation was observed between 25OHD and osteocalcin levels. All the other molecules were unchanged. 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subjects Acute Disease
Aged
Aged patients
Alkaline Phosphatase - blood
Aneurysm, Dissecting - blood
Calcium - blood
Dissecting aneurysm
Female
Health aspects
Humans
Laboratories
Male
Measurement
Middle Aged
Osteocalcin - blood
Parathyroid Hormone - blood
Physiological aspects
Pilot Projects
Protein hormones
Studies
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin deficiency
title Vitamin D Deficiency Is Associated with Increased Osteocalcin Levels in Acute Aortic Dissection: A Pilot Study on Elderly Patients
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