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Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey
Abstract Introduction Inherited bleeding disorders vary in prevalence due to genetic disparity and ethnicity. Little is known about the prevalence of coagulation factor deficiency and bleeding disorders in middle-eastern population. Methods Young Saudi adults with at least one positive bleeding sy...
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| Published in: | TH open : companion journal to thrombosis and haemostasis 2020-10, Vol.4 (4), p.e457-e462 |
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| creator | AlSaleh, Khalid A. Al-Numair, Nouf AlSuliman, Ayman Zolaly, Mohammed Albanyan, Abdul Majeed AlOtaishan, Nouf Abudouleh, Esra Bayoumy, Nervana Tarawah, Ahmad AlZahrani, Faisal AlAllaf, Faisal AlMomen, Abdul kareem Sajid, Raihan Owaidah, Tarek M. |
| description | Abstract
Introduction
Inherited bleeding disorders vary in prevalence due to genetic disparity and ethnicity. Little is known about the prevalence of coagulation factor deficiency and bleeding disorders in middle-eastern population.
Methods
Young Saudi adults with at least one positive bleeding symptom reported in semi-structured validated condensed MCMDM-1vWD questionnaire were tested for complete blood count, routine and special coagulation tests, serum ferritin level, and capillary zone electrophoresis. After initial testing, those with prolonged prothrombin time (PT) or activated prothrombin time (APTT) had further testing to evaluate coagulation factors level. Platelet function was tested through platelet function analyzer (PFA)-100, and multiplate aggregometer (MEA) on patients suspected of having platelet disorders.
Results
Six-hundred-forty patients (male = 347, 54.2%) were included. A possible platelet function defect was diagnosed in three patients with one matching Glanzmann's thrombasthenia trait pattern, and one that of Bernard-Soulier trait pattern. One patient was diagnosed with von Willebrand disease. Deficiencies in coagulation factor levels were revealed as F-VIII in 14 (7.4%), F-IX in 15 (7.6%), F-II in two (3.3%), F-V in 17 (26.1%), FVII in two (3.1%), and F-X in one (1.8%) of study subjects; low vWF activity ( |
| doi_str_mv | 10.1055/s-0040-1721500 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_4752f5a6cf364245920ca92d4a5b1826</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_4752f5a6cf364245920ca92d4a5b1826</doaj_id><sourcerecordid>2473901687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3390-53c34f14f353d8c8ff116fa624a1311d8eef84e32a9916c2803ea4ca1e3c2133</originalsourceid><addsrcrecordid>eNp1kT1PHDEQhldRooAIbcrIZZolHn_sR4pIpyMEJJREgiaVNecdHz7trom9e9L9-xjuQFCksS37mWc8eoviI_Az4Fp_SSXnipdQC9CcvymOhQZRtqrSb1-cj4rTlDacc2ihEqJ9XxxJKeuqVfq4WP2OtMWeRkssOLYMuJ57nHwY2QXaKcTEzsl56zOxYziEcc3-hDmvi27up8T8yG5w7jxbRFx5_MoW7OdjPfbsZo5b2n0o3jnsE50e9pPi9uL77fKyvP7142q5uC6tlC0vtbRSOVBOatk1tnEOoHJYCYUgAbqGyDWKpMA2z2FFwyWhsggkrQApT4qrvbYLuDH30Q8YdyagN48XIa4NxsnbnoyqtXAaK-tkpYTSreAWW9Ep1CtoRJVd3_au-3k1UGdpnCL2r6SvX0Z_Z9Zha-paN6BVFnw-CGL4O1OazOCTpb7HkcKcjFB1nhmqps7o2R61MaQUyT23AW4eYjbJPMRsDjHngk8vP_eMP4WagXIPTHeeBjKbMMccR_qf8B9ucq_I</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473901687</pqid></control><display><type>article</type><title>Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey</title><source>PubMed Central</source><source>Thieme Connect Journals Open Access</source><creator>AlSaleh, Khalid A. ; Al-Numair, Nouf ; AlSuliman, Ayman ; Zolaly, Mohammed ; Albanyan, Abdul Majeed ; AlOtaishan, Nouf ; Abudouleh, Esra ; Bayoumy, Nervana ; Tarawah, Ahmad ; AlZahrani, Faisal ; AlAllaf, Faisal ; AlMomen, Abdul kareem ; Sajid, Raihan ; Owaidah, Tarek M.</creator><creatorcontrib>AlSaleh, Khalid A. ; Al-Numair, Nouf ; AlSuliman, Ayman ; Zolaly, Mohammed ; Albanyan, Abdul Majeed ; AlOtaishan, Nouf ; Abudouleh, Esra ; Bayoumy, Nervana ; Tarawah, Ahmad ; AlZahrani, Faisal ; AlAllaf, Faisal ; AlMomen, Abdul kareem ; Sajid, Raihan ; Owaidah, Tarek M.</creatorcontrib><description>Abstract
Introduction
Inherited bleeding disorders vary in prevalence due to genetic disparity and ethnicity. Little is known about the prevalence of coagulation factor deficiency and bleeding disorders in middle-eastern population.
Methods
Young Saudi adults with at least one positive bleeding symptom reported in semi-structured validated condensed MCMDM-1vWD questionnaire were tested for complete blood count, routine and special coagulation tests, serum ferritin level, and capillary zone electrophoresis. After initial testing, those with prolonged prothrombin time (PT) or activated prothrombin time (APTT) had further testing to evaluate coagulation factors level. Platelet function was tested through platelet function analyzer (PFA)-100, and multiplate aggregometer (MEA) on patients suspected of having platelet disorders.
Results
Six-hundred-forty patients (male = 347, 54.2%) were included. A possible platelet function defect was diagnosed in three patients with one matching Glanzmann's thrombasthenia trait pattern, and one that of Bernard-Soulier trait pattern. One patient was diagnosed with von Willebrand disease. Deficiencies in coagulation factor levels were revealed as F-VIII in 14 (7.4%), F-IX in 15 (7.6%), F-II in two (3.3%), F-V in 17 (26.1%), FVII in two (3.1%), and F-X in one (1.8%) of study subjects; low vWF activity (<50%) was found in 14 (8%). Abnormal values were found for various laboratory tests with prolongation of platelet function analyzer-epinephrine (PFA-EPI) in 11%, PFA-ADP or arachidonic acid in 15.2%, PT in 35.9%, and APTT in 63.7%. Five-hundred-seventy-six patients (90%) had normal results in the coagulation factor assays and were categorized as patients with bleeding of unknown cause (BUC). A diagnosis of a bleeding disorder was more frequently made in men than in women (38 vs. 26). Iron deficiency anemia was found in 18 (25%) females positively associated with F-IX deficiency (
p
-value 0.000). Male gender (73.3%,
p
= 0.007) was independently associated with the diagnosis of coagulation factor deficiency.
Conclusion
The current study reports a higher prevalence of coagulation factors deficiency in Saudi population than reported in the western population.</description><identifier>ISSN: 2512-9465</identifier><identifier>ISSN: 2567-3459</identifier><identifier>EISSN: 2512-9465</identifier><identifier>DOI: 10.1055/s-0040-1721500</identifier><identifier>PMID: 33376945</identifier><language>eng</language><publisher>Rüdigerstraße 14, 70469 Stuttgart, Germany: Georg Thieme Verlag KG</publisher><subject>bleeding ; coagulation ; inherited ; Original ; Original Article</subject><ispartof>TH open : companion journal to thrombosis and haemostasis, 2020-10, Vol.4 (4), p.e457-e462</ispartof><rights>The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited.</rights><rights>The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).</rights><rights>The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( ) 2020 The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3390-53c34f14f353d8c8ff116fa624a1311d8eef84e32a9916c2803ea4ca1e3c2133</citedby><cites>FETCH-LOGICAL-c3390-53c34f14f353d8c8ff116fa624a1311d8eef84e32a9916c2803ea4ca1e3c2133</cites><orcidid>0000-0002-2729-856X ; 0000-0002-9399-300X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758154/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758154/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,20871,27903,27904,53769,53771,54565,54593</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33376945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AlSaleh, Khalid A.</creatorcontrib><creatorcontrib>Al-Numair, Nouf</creatorcontrib><creatorcontrib>AlSuliman, Ayman</creatorcontrib><creatorcontrib>Zolaly, Mohammed</creatorcontrib><creatorcontrib>Albanyan, Abdul Majeed</creatorcontrib><creatorcontrib>AlOtaishan, Nouf</creatorcontrib><creatorcontrib>Abudouleh, Esra</creatorcontrib><creatorcontrib>Bayoumy, Nervana</creatorcontrib><creatorcontrib>Tarawah, Ahmad</creatorcontrib><creatorcontrib>AlZahrani, Faisal</creatorcontrib><creatorcontrib>AlAllaf, Faisal</creatorcontrib><creatorcontrib>AlMomen, Abdul kareem</creatorcontrib><creatorcontrib>Sajid, Raihan</creatorcontrib><creatorcontrib>Owaidah, Tarek M.</creatorcontrib><title>Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey</title><title>TH open : companion journal to thrombosis and haemostasis</title><addtitle>TH Open</addtitle><description>Abstract
Introduction
Inherited bleeding disorders vary in prevalence due to genetic disparity and ethnicity. Little is known about the prevalence of coagulation factor deficiency and bleeding disorders in middle-eastern population.
Methods
Young Saudi adults with at least one positive bleeding symptom reported in semi-structured validated condensed MCMDM-1vWD questionnaire were tested for complete blood count, routine and special coagulation tests, serum ferritin level, and capillary zone electrophoresis. After initial testing, those with prolonged prothrombin time (PT) or activated prothrombin time (APTT) had further testing to evaluate coagulation factors level. Platelet function was tested through platelet function analyzer (PFA)-100, and multiplate aggregometer (MEA) on patients suspected of having platelet disorders.
Results
Six-hundred-forty patients (male = 347, 54.2%) were included. A possible platelet function defect was diagnosed in three patients with one matching Glanzmann's thrombasthenia trait pattern, and one that of Bernard-Soulier trait pattern. One patient was diagnosed with von Willebrand disease. Deficiencies in coagulation factor levels were revealed as F-VIII in 14 (7.4%), F-IX in 15 (7.6%), F-II in two (3.3%), F-V in 17 (26.1%), FVII in two (3.1%), and F-X in one (1.8%) of study subjects; low vWF activity (<50%) was found in 14 (8%). Abnormal values were found for various laboratory tests with prolongation of platelet function analyzer-epinephrine (PFA-EPI) in 11%, PFA-ADP or arachidonic acid in 15.2%, PT in 35.9%, and APTT in 63.7%. Five-hundred-seventy-six patients (90%) had normal results in the coagulation factor assays and were categorized as patients with bleeding of unknown cause (BUC). A diagnosis of a bleeding disorder was more frequently made in men than in women (38 vs. 26). Iron deficiency anemia was found in 18 (25%) females positively associated with F-IX deficiency (
p
-value 0.000). Male gender (73.3%,
p
= 0.007) was independently associated with the diagnosis of coagulation factor deficiency.
Conclusion
The current study reports a higher prevalence of coagulation factors deficiency in Saudi population than reported in the western population.</description><subject>bleeding</subject><subject>coagulation</subject><subject>inherited</subject><subject>Original</subject><subject>Original Article</subject><issn>2512-9465</issn><issn>2567-3459</issn><issn>2512-9465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><sourceid>DOA</sourceid><recordid>eNp1kT1PHDEQhldRooAIbcrIZZolHn_sR4pIpyMEJJREgiaVNecdHz7trom9e9L9-xjuQFCksS37mWc8eoviI_Az4Fp_SSXnipdQC9CcvymOhQZRtqrSb1-cj4rTlDacc2ihEqJ9XxxJKeuqVfq4WP2OtMWeRkssOLYMuJ57nHwY2QXaKcTEzsl56zOxYziEcc3-hDmvi27up8T8yG5w7jxbRFx5_MoW7OdjPfbsZo5b2n0o3jnsE50e9pPi9uL77fKyvP7142q5uC6tlC0vtbRSOVBOatk1tnEOoHJYCYUgAbqGyDWKpMA2z2FFwyWhsggkrQApT4qrvbYLuDH30Q8YdyagN48XIa4NxsnbnoyqtXAaK-tkpYTSreAWW9Ep1CtoRJVd3_au-3k1UGdpnCL2r6SvX0Z_Z9Zha-paN6BVFnw-CGL4O1OazOCTpb7HkcKcjFB1nhmqps7o2R61MaQUyT23AW4eYjbJPMRsDjHngk8vP_eMP4WagXIPTHeeBjKbMMccR_qf8B9ucq_I</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>AlSaleh, Khalid A.</creator><creator>Al-Numair, Nouf</creator><creator>AlSuliman, Ayman</creator><creator>Zolaly, Mohammed</creator><creator>Albanyan, Abdul Majeed</creator><creator>AlOtaishan, Nouf</creator><creator>Abudouleh, Esra</creator><creator>Bayoumy, Nervana</creator><creator>Tarawah, Ahmad</creator><creator>AlZahrani, Faisal</creator><creator>AlAllaf, Faisal</creator><creator>AlMomen, Abdul kareem</creator><creator>Sajid, Raihan</creator><creator>Owaidah, Tarek M.</creator><general>Georg Thieme Verlag KG</general><scope>0U6</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2729-856X</orcidid><orcidid>https://orcid.org/0000-0002-9399-300X</orcidid></search><sort><creationdate>202010</creationdate><title>Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey</title><author>AlSaleh, Khalid A. ; Al-Numair, Nouf ; AlSuliman, Ayman ; Zolaly, Mohammed ; Albanyan, Abdul Majeed ; AlOtaishan, Nouf ; Abudouleh, Esra ; Bayoumy, Nervana ; Tarawah, Ahmad ; AlZahrani, Faisal ; AlAllaf, Faisal ; AlMomen, Abdul kareem ; Sajid, Raihan ; Owaidah, Tarek M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3390-53c34f14f353d8c8ff116fa624a1311d8eef84e32a9916c2803ea4ca1e3c2133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>bleeding</topic><topic>coagulation</topic><topic>inherited</topic><topic>Original</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AlSaleh, Khalid A.</creatorcontrib><creatorcontrib>Al-Numair, Nouf</creatorcontrib><creatorcontrib>AlSuliman, Ayman</creatorcontrib><creatorcontrib>Zolaly, Mohammed</creatorcontrib><creatorcontrib>Albanyan, Abdul Majeed</creatorcontrib><creatorcontrib>AlOtaishan, Nouf</creatorcontrib><creatorcontrib>Abudouleh, Esra</creatorcontrib><creatorcontrib>Bayoumy, Nervana</creatorcontrib><creatorcontrib>Tarawah, Ahmad</creatorcontrib><creatorcontrib>AlZahrani, Faisal</creatorcontrib><creatorcontrib>AlAllaf, Faisal</creatorcontrib><creatorcontrib>AlMomen, Abdul kareem</creatorcontrib><creatorcontrib>Sajid, Raihan</creatorcontrib><creatorcontrib>Owaidah, Tarek M.</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>TH open : companion journal to thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AlSaleh, Khalid A.</au><au>Al-Numair, Nouf</au><au>AlSuliman, Ayman</au><au>Zolaly, Mohammed</au><au>Albanyan, Abdul Majeed</au><au>AlOtaishan, Nouf</au><au>Abudouleh, Esra</au><au>Bayoumy, Nervana</au><au>Tarawah, Ahmad</au><au>AlZahrani, Faisal</au><au>AlAllaf, Faisal</au><au>AlMomen, Abdul kareem</au><au>Sajid, Raihan</au><au>Owaidah, Tarek M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey</atitle><jtitle>TH open : companion journal to thrombosis and haemostasis</jtitle><addtitle>TH Open</addtitle><date>2020-10</date><risdate>2020</risdate><volume>4</volume><issue>4</issue><spage>e457</spage><epage>e462</epage><pages>e457-e462</pages><issn>2512-9465</issn><issn>2567-3459</issn><eissn>2512-9465</eissn><abstract>Abstract
Introduction
Inherited bleeding disorders vary in prevalence due to genetic disparity and ethnicity. Little is known about the prevalence of coagulation factor deficiency and bleeding disorders in middle-eastern population.
Methods
Young Saudi adults with at least one positive bleeding symptom reported in semi-structured validated condensed MCMDM-1vWD questionnaire were tested for complete blood count, routine and special coagulation tests, serum ferritin level, and capillary zone electrophoresis. After initial testing, those with prolonged prothrombin time (PT) or activated prothrombin time (APTT) had further testing to evaluate coagulation factors level. Platelet function was tested through platelet function analyzer (PFA)-100, and multiplate aggregometer (MEA) on patients suspected of having platelet disorders.
Results
Six-hundred-forty patients (male = 347, 54.2%) were included. A possible platelet function defect was diagnosed in three patients with one matching Glanzmann's thrombasthenia trait pattern, and one that of Bernard-Soulier trait pattern. One patient was diagnosed with von Willebrand disease. Deficiencies in coagulation factor levels were revealed as F-VIII in 14 (7.4%), F-IX in 15 (7.6%), F-II in two (3.3%), F-V in 17 (26.1%), FVII in two (3.1%), and F-X in one (1.8%) of study subjects; low vWF activity (<50%) was found in 14 (8%). Abnormal values were found for various laboratory tests with prolongation of platelet function analyzer-epinephrine (PFA-EPI) in 11%, PFA-ADP or arachidonic acid in 15.2%, PT in 35.9%, and APTT in 63.7%. Five-hundred-seventy-six patients (90%) had normal results in the coagulation factor assays and were categorized as patients with bleeding of unknown cause (BUC). A diagnosis of a bleeding disorder was more frequently made in men than in women (38 vs. 26). Iron deficiency anemia was found in 18 (25%) females positively associated with F-IX deficiency (
p
-value 0.000). Male gender (73.3%,
p
= 0.007) was independently associated with the diagnosis of coagulation factor deficiency.
Conclusion
The current study reports a higher prevalence of coagulation factors deficiency in Saudi population than reported in the western population.</abstract><cop>Rüdigerstraße 14, 70469 Stuttgart, Germany</cop><pub>Georg Thieme Verlag KG</pub><pmid>33376945</pmid><doi>10.1055/s-0040-1721500</doi><orcidid>https://orcid.org/0000-0002-2729-856X</orcidid><orcidid>https://orcid.org/0000-0002-9399-300X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2512-9465 |
| ispartof | TH open : companion journal to thrombosis and haemostasis, 2020-10, Vol.4 (4), p.e457-e462 |
| issn | 2512-9465 2567-3459 2512-9465 |
| language | eng |
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| source | PubMed Central; Thieme Connect Journals Open Access |
| subjects | bleeding coagulation inherited Original Original Article |
| title | Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey |
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