BIAPSS: A Comprehensive Physicochemical Analyzer of Proteins Undergoing Liquid-Liquid Phase Separation

The liquid-liquid phase separation (LLPS) of biomolecules is a phenomenon which is nowadays recognized as the driving force for the biogenesis of numerous functional membraneless organelles and cellular bodies. The interplay between the protein primary sequence and phase separation remains poorly un...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (11), p.6204
Main Authors: Badaczewska-Dawid, Aleksandra E, Uversky, Vladimir N, Potoyan, Davit A
Format: Article
Language:English
Subjects:
Amino acid sequence
Amino acids
Bioinformatics
Biomolecules
intrinsically disordered proteins
Intrinsically Disordered Proteins - chemistry
Liquid phases
liquid–liquid phase separation
membraneless organelles
Organelles
Organelles - metabolism
Phase separation
Proteins
proteins with low complexity
Statistical analysis
Trends
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Summary:The liquid-liquid phase separation (LLPS) of biomolecules is a phenomenon which is nowadays recognized as the driving force for the biogenesis of numerous functional membraneless organelles and cellular bodies. The interplay between the protein primary sequence and phase separation remains poorly understood, despite intensive research. To uncover the sequence-encoded signals of protein capable of undergoing LLPS, we developed a novel web platform named BIAPSS (Bioinformatics Analysis of LLPS Sequences). This web server provides on-the-fly analysis, visualization, and interpretation of the physicochemical and structural features for the superset of curated LLPS proteins.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23116204