Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review

Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA other than surgery. The exploration of the mechanisms of occurrence is important in exploring other new and effective...

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Bibliographic Details
Published in:Cell communication and signaling 2023-04, Vol.21 (1), p.67-67, Article 67
Main Authors: Chen, Bo, Ning, Ke, Sun, Ming-Li, Zhang, Xin-An
Format: Article
Language:English
Subjects:
Apoptosis
Arthritis
Cartilage
Cartilage (articular)
Cartilage diseases
Cartilage, Articular - metabolism
Chondrocytes - metabolism
Cytoplasm
Degeneration
Disease
DNA methylation
Homeostasis
Humans
JAK2/STAT3
Janus kinase
Janus kinase 2
Janus Kinase 2 - metabolism
Kinases
Mechanism
Nonsteroidal anti-inflammatory drugs
Older people
Osteoarthritis
Osteoarthritis - metabolism
Pathogenesis
Pathway
Phosphorylation
Review
Reviews
Signal Transduction
Stat3 protein
STAT3 Transcription Factor - metabolism
Subchondral bone
Targeted therapy
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Summary:Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA other than surgery. The exploration of the mechanisms of occurrence is important in exploring other new and effective treatments for OA. The current evidence shows that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays a vital role in cytogenesis and is involved in OA progression. The terms "JAK2", "STAT3", and "Osteoarthritis"were used in a comprehensive literature search in PubMed to further investigate the relationship between the JAK2/STAT3 signaling pathway and OA. This review focuses on the role and mechanism of JAK2/STAT3 signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation. In addition, this review summarizes recent evidence of therapeutic approaches to treat OA by targeting the JAK2/STAT3 pathway to accelerate the translation of evidence into the progression of strategies for OA treatment. Video abstract.
ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-023-01094-4