Nonspecific Regulation of the Number of Immunocompetent Cells Under the Influence of DT Toxoid in Children With Glomerulonephritis

• Published in: Frontiers in immunology 2021-10, Vol.12, p.715389-715389
• Main Authors: Kostinov, Mikhail Petrovich, Akhmatova, Nelli Kimovna, Magarshak, Olga Olegovna, Vlasenko, Anna Egorovna, Polishchuk, Valentina Borisovna, Kostinova, Aristitsa Mikhailovna, Mashilov, Kirill Vadimovich
• Format: Article
• Language: English
• Subjects: Adolescent; Age Factors; Antibodies, Bacterial - blood; Antibodies, Bacterial - immunology; Case-Control Studies; Child; Child, Preschool; Comorbidity; diphtheria and tetanus toxoid; Female; glomerulonephritis; Glomerulonephritis - immunology; Glomerulonephritis - metabolism; Glomerulonephritis - pathology; Glomerulonephritis - therapy; Humans; Immunity; Immunization, Secondary; Immunoglobulin G - immunology; Immunology; Immunomodulation; Lymphocyte Count; Male; post-vaccination antibodies; T-Lymphocytes; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tetanus Toxoid - administration & dosage; Tetanus Toxoid - immunology; Vaccination; vaccination in children
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2021.715389

Studies aimed at identifying the mechanisms of the immunoregulatory effect of vaccination with diphtheria and tetanus toxoid on the parameters of adaptive immunity in children with kidney pathology are limited. The study aimed to study the effect of revaccination against diphtheria and tetanus on the proliferation and differentiation of immunocompetent cells, the formation of specific antibodies, and the course of the disease in children with glomerulonephritis (GN). The study included 45 children with glomerulonephritis (GN) aged 5 to 15 years, in remission from 6 months up to 4 years. Of these, 25 children were revaccinated with DT toxoid (Diphtheria-Tetanus toxoid with reduced antigenic content) and 20 were in the control group (not vaccinated). The frequency of development of local and systemic reactions and the course of GN were assessed. The subpopulation structure of lymphocytes was studied in dynamics after 1-6-12 months by flow cytometry and IgG levels to diphtheria and tetanus were studied by ELISA. In 92% of children with GN, the post-vaccination period was uneventful. 8% showed a rise in temperature up to 37.3 C, without the development of local reactions. During the year, none of the patients had an exacerbation of GN or a concomitant disease. After revaccination with DT toxoid, a significant increase in IgG antibodies against diphtheria and tetanus was revealed, which persisted after 12 months - 7.5 [5.1-10.8] IU/mL (p