Calcium Carbonate Nanoparticles-Toxicity and Effect of In Ovo Inoculation on Chicken Embryo Development, Broiler Performance and Bone Status

The use of intensive selection procedure in modern broiler chicken lines has led to the development of several skeletal disorders in broiler chickens. Therefore, current research is focused on methods to improve the bone quality in birds. In ovo technology, using nanoparticles with a high specificit...

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Bibliographic Details
Published in:Animals (Basel) 2021-03, Vol.11 (4), p.932
Main Authors: Matuszewski, Arkadiusz, Łukasiewicz, Monika, Niemiec, Jan, Kamaszewski, Maciej, Jaworski, Sławomir, Domino, Małgorzata, Jasiński, Tomasz, Chwalibog, André, Sawosz, Ewa
Format: Article
Language:English
Subjects:
Birds
bone quality
Bones
broiler
Calcification
Calcium carbonate
Cell growth
Cell viability
chicken embryo
Chickens
Cytotoxicity
Dietary minerals
Eggs
Embryogenesis
Embryonic growth stage
Embryos
Enzymes
Hatchability
Humidity
Hydroxyapatite
Injection
Inoculation
Meat
Meat quality
Mineralization
Nanoparticles
Nutrition
Particle size
Poultry
Quality assessment
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Summary:The use of intensive selection procedure in modern broiler chicken lines has led to the development of several skeletal disorders in broiler chickens. Therefore, current research is focused on methods to improve the bone quality in birds. In ovo technology, using nanoparticles with a high specificity to bones, is a potential approach. The present study aimed to evaluate the effect of in ovo inoculation (IOI) of calcium carbonate nanoparticles (CCN) on chicken embryo development, health status, bone characteristics, and on broiler production results and bone quality. After assessing in vitro cell viability, the IOI procedure was performed with an injection of 500 μg/mL CCN. The control group was not inoculated with CCN. Hatchability, weight, and selected bone and serum parameters were measured in embryos. Part of hatchlings were reared under standard conditions until 42 days, and production results, meat quality, and bone quality of broilers were determined. CCN did not show cytotoxicity to cells and chicken embryo and positively influenced bone parameters of the embryos and of broilers later (calcification) without negatively affecting the production results. Thus, the IOI of CCN could modify the molecular responses at the stage of embryogenesis, resulting in better mineralization, and could provide a sustained effect, thereby improving bone quality in adult birds.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani11040932