An exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis

Background Exploration of biomarkers for debilitating diseases such as cervical spondylosis is important to revolutionize clinical diagnosis and management of such conditions. The study aimed to determine the correlation between neck pain and disability and serum levels of interleukin-6 (IL-6), oste...

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Published in:Bulletin of Faculty of Physical Therapy (Online) 2023-12, Vol.28 (1), p.29-10, Article 29
Main Authors: Igwe, Augustine Asiduba, Onyeso, Ogochukwu Kelechi, Adandom, Israel, Onyeso, Kelechi Mirabel, Anyachukwu, Canice Chukwudi, Awosoga, Oluwagbohunmi A., Ezema, Charles Ikechukwu, Okoye, Goddy Chuba
Format: Article
Language:English
Subjects:
Arthritis
Biomarkers
Body mass index
Bone remodeling
Cohort analysis
Cytokines
Data collection
Disability evaluation
Gender
Hormones
Hospitals
Intervertebral disc degeneration
Medical research
Medicine
Medicine & Public Health
Neck pain
Original Research Article
Orthopedics
Physical therapy
Sample size
Sociodemographics
Testosterone
Traction (Orthopedics)
Variables
Womens health
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Summary:Background Exploration of biomarkers for debilitating diseases such as cervical spondylosis is important to revolutionize clinical diagnosis and management of such conditions. The study aimed to determine the correlation between neck pain and disability and serum levels of interleukin-6 (IL-6), osteoprotegerin (OPG), estradiol (E2), testosterone (TES), calcium (Ca), and magnesium (Mg) among individuals with symptomatic cervical spondylosis. Methods This study was a cohort design. The participants were new referrals to two Nigerian physical therapy clinics. Participants’ neck pain intensity (PI), neck disability index (NDI), IL-6, OPG, E2, TES, Ca, and Mg were measured at baseline and after 13 weeks of follow-up. Data were analyzed using descriptive statistics, independent samples t test, Pearson’s correlation, and multiple linear regression. Results Forty individuals aged 52.40 ± 8.60 years participated in the study. Women had significantly higher levels of IL-6 ( t  =  − 2.392, p  = 0.026), OPG ( t  =  − 3.235, p  = 0.005), E2 ( t  =  − 6.841, p  = 0.001), but lower TES ( t  = 17.776, p  = 0.001). There were no significant sex differences in PI and NDI. There were significant correlations between PI and OPG ( r  = 0.385, p  
ISSN:2536-9660
1110-6611
2536-9660
DOI:10.1186/s43161-023-00141-y