Factors associated with the development of epilepsy in very low birth weight infants

The survival rate of very low birth weight (VLBW) infants has recently improved. However, the occurrence of and factors associated with epilepsy in VLBW infants remain unknown. This study aimed to clarify the incidence, characteristics, and factors associated with epilepsy development in VLBW infant...

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Published in:Pediatrics and neonatology 2023-11, Vol.64 (6), p.637-643
Main Authors: Fukao, Toshimichi, Sano, Fumikazu, Nemoto, Atsushi, Naito, Atsushi, Yanagisawa, Toshimitsu, Imai, Ken, Hiroma, Takehiko, Inaba, Yuji, Kanemura, Hideaki, Aihara, Masao, Inukai, Takeshi, Kaga, Yoshimi
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Language:English
Subjects:
Cysticperiventricular leukomalacia
Epilepsy
Hypoxic ischemic encephalopathy
Intraventricular hemorrhage
Very low birth weight infants
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Kanemura, Hideaki
Aihara, Masao
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Kaga, Yoshimi
description The survival rate of very low birth weight (VLBW) infants has recently improved. However, the occurrence of and factors associated with epilepsy in VLBW infants remain unknown. This study aimed to clarify the incidence, characteristics, and factors associated with epilepsy development in VLBW infants. All VLBW infants admitted to our hospital between 2012 and 2017 were included in this study. VLBW infants with a follow-up period of
doi_str_mv 10.1016/j.pedneo.2022.12.019
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However, the occurrence of and factors associated with epilepsy in VLBW infants remain unknown. This study aimed to clarify the incidence, characteristics, and factors associated with epilepsy development in VLBW infants. All VLBW infants admitted to our hospital between 2012 and 2017 were included in this study. VLBW infants with a follow-up period of &lt;1 year were excluded. Chromosomal abnormalities, brain anomalies, severe intraventricular hemorrhage (IVH), cystic periventricular leukomalacia (PVL), and hypoxic ischemic encephalopathy (HIE) were considered to be risk factors. Epilepsy occurred in 21/526 (4.0%) VLBW infants. Chromosomal abnormalities, brain anomalies, severe IVH, cystic PVL, HIE, neonatal seizures, advanced maternal age, maternal diabetes mellitus, no administration of antenatal corticosteroids, and low Apgar scores at 1 and 5 min were associated with a risk of epilepsy. The median time to epilepsy onset was 8 months (range: 0–59 months), and the onset occurred within 2 years in 15/21 patients (71.4%) and within 4 years in 18/21 patients (85.7%). VLBW infants with risk factors developed epilepsy earlier and at a significantly higher rate than those without risk factors. Among infants who had risk factors and who developed epilepsy, 86.7% did so within 2 years of age, compared to 33.3% of those who developed epilepsy but did not have risk factors. 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subjects Cysticperiventricular leukomalacia
Epilepsy
Hypoxic ischemic encephalopathy
Intraventricular hemorrhage
Very low birth weight infants
title Factors associated with the development of epilepsy in very low birth weight infants
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