Association between tea, coffee and caffeine consumption and risk of female infertility: a cross-sectional study

• Published in: Reproductive biology and endocrinology 2024-07, Vol.22 (1), p.91-9, Article 91
• Main Authors: Zhang, Hanzhi, Qian, Sixu, Chen, Jianlin, Chen, Jingfei
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Caffeine; Caffeine - administration & dosage; Caffeine - adverse effects; Caffeine intake; Coffee - adverse effects; Coffee consumption; Cross-Sectional Studies; Cross-sectional study; Female; Health aspects; Humans; Infertility; Infertility, Female; Infertility, Female - epidemiology; Lifestyle; Nutrition Surveys; Nutritional aspects; Prevention; Risk Factors; Surveys; Tea; Tea - adverse effects; Tea consumption; Young Adult
• ISSN: 1477-7827; 1477-7827
• DOI: 10.1186/s12958-024-01261-3

To explore the association between tea, coffee, and caffeine consumption and the risk of female infertility. We analyzed data from 2099 females aged 18 to 44 years, participating in the National Health and Nutrition Examination Survey (NHANES) 2013-2018. We used generalized linear models (GLM) and generalized additive model (GAM) to investigate the dose-response relationship between the tea, coffee, and caffeine consumption and infertility, adjusting for potential confounders. A non-linear relationship was detected between tea consumption and infertility and the inflection point was 2 cups/day. On the right side of the inflection point, we did not detect a significant association. However, on the left side, we found a negative relationship between tea consumption and infertility (OR: 0.73; 95% CI: 0.57 to 0.93; P = 0.0122). Meanwhile, our study found no significant association between coffee (0.96, 0.81 to 1.13, P = 0.6189) or caffeine consumption (1.15, 0.93 to 1.42, P = 0.2148) and female infertility. Tea consumption was non-linearly associated with infertility, whereas no significant associations were found between coffee, caffeine consumption and infertility.