Time-dependent change of relative apical longitudinal strain index in patients with wild-type transthyretin amyloid cardiomyopathy

This study was conducted to investigate the meaning of left ventricular (LV) apical sparing in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). 165 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from January 2002 to December 2020 and had sufficien...

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Published in:International journal of cardiology. Heart & vasculature 2022-12, Vol.43, p.101146-101146, Article 101146
Main Authors: Usuku, Hiroki, Yamamoto, Eiichiro, Sueta, Daisuke, Noguchi, Momoko, Fujisaki, Tomohiro, Egashira, Koichi, Morioka, Mami, Komorita, Takashi, Oike, Fumi, Fujisue, Koichiro, Hanatani, Shinsuke, Arima, Yuichiro, Takashio, Seiji, Oda, Seitaro, Kawano, Hiroaki, Matsushita, Kenichi, Ueda, Mitsuharu, Matsui, Hirotaka, Tsujita, Kenichi
Format: Article
Language:English
Subjects:
Echocardiography
Left ventricular apical sparing
Longitudinal strain
Original Paper
Two-dimensional speckle tracking echocardiography
Wild-type transthyretin amyloid cardiomyopathy
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Summary:This study was conducted to investigate the meaning of left ventricular (LV) apical sparing in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). 165 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from January 2002 to December 2020 and had sufficient data for two-dimensional speckle tracking echocardiography were enrolled. Of these, 86 patients (52 %) had LV apical sparing (relative apical longitudinal strain index (RapLSI) > 1.0). Multivariable logistic regression analysis revealed the following variables were significantly associated with LV apical sparing: interventricular septal thickness in diastole (odds ratio (OR), 1.19; 95 % confidence interval (CI), 1.01–1.41; p 
ISSN:2352-9067
2352-9067
DOI:10.1016/j.ijcha.2022.101146