The roles of exosomes in cancer drug resistance and its therapeutic application

Exosomes are a category of extracellular vesicles with a size ranging from 40 to 160 nm, which can be secreted by multiple cells in the tumor microenvironment. Exosomes serve as communicators in regulating biological functions and pathological processes, including drug response. Through transporting...

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Bibliographic Details
Published in:Clinical and translational medicine 2020-12, Vol.10 (8), p.e257-n/a
Main Authors: Li, Shiyu, Yi, Ming, Dong, Bing, Jiao, Ying, Luo, Suxia, Wu, Kongming
Format: Article
Language:English
Subjects:
cancer
drug resistance
exosomes
Review
Reviews
therapeutic application
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Summary:Exosomes are a category of extracellular vesicles with a size ranging from 40 to 160 nm, which can be secreted by multiple cells in the tumor microenvironment. Exosomes serve as communicators in regulating biological functions and pathological processes, including drug response. Through transporting the cargo such as protein or nucleic acid, exosomes can modulate drug sensitivity via multiple mechanisms. Additionally, exosomes can be deployed as a delivery system to treat cancer due to their high‐efficient loading capacity and tolerable toxicity. Recent studies have demonstrated the high efficacy of exosomes in cancer therapy. Herein, we conduct this review to summarize the mechanism of exosome‐mediated drug resistance and the therapeutic potential of exosomes in cancer. The mechanisms of exosome‐induced cancer drug resistance are elaborated. The potential therapeutic application of exosomes is discussed in great detail.
ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.257