Impact of Sleep Respiratory Disorders on Endothelial Function in Children

Obstructive sleep apnea syndrome (OSAS) in children can induce endothelial dysfunction, a well-known early marker of atherosclerosis. The study aimed to evaluate a link among endothelial function (measured by flow-mediated vasodilation (FMD)), obesity (evaluated by body mass index (BMI)), and sleep...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-6
Main Authors: Ciccone, Marco Matteo, Miniello, Vito Leonardo, Giordano, Paola, Sassara, Marco, Fornarelli, Fara, Zito, Annapaola, Gesualdo, Michele, Scicchitano, Pietro, Tranchino, Valentina, Loscialpo, Maria, Francavilla, Ruggiero, Brunetti, Luigia
Format: Article
Language:English
Subjects:
Age
Atherosclerosis
Blood Flow Velocity
Body mass index
Body size
Brachial Artery - physiopathology
Child
Clinical Study
Cytokines
Endothelium, Vascular - physiopathology
Evaluation
Families & family life
Family medical history
Female
Health risks
Humans
Male
Pediatrics
Population
Reproducibility of Results
Respiratory diseases
Risk assessment
Sensitivity and Specificity
Sleep
Sleep Apnea Syndromes - physiopathology
Studies
Values
Vasodilation
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Summary:Obstructive sleep apnea syndrome (OSAS) in children can induce endothelial dysfunction, a well-known early marker of atherosclerosis. The study aimed to evaluate a link among endothelial function (measured by flow-mediated vasodilation (FMD)), obesity (evaluated by body mass index (BMI)), and sleep disordered breathing (SDB), assessed with apnoea/hypopnoea index (AHI), in a paediatric population. We demonstrated that our little OSAS patients showed an impaired endothelial function as compared to controls. In particular, the higher the AHI, the worst the FMD values and thus the endothelial function. Although the population sample is small, this study demonstrated that OSAS could impair endothelial function and worsen cardiovascular risk profile since childhood.
ISSN:2356-6140
1537-744X
DOI:10.1155/2013/719456