Reductive effect of ursodeoxycholic acid on bilirubin levels in neonates on phototherapy

Phototherapy is paramount in the management of high total serum bilirubin (TSB). Whether its effectiveness can be improved with ursodeoxycholic acid (UDCA) has not been evaluated among newborns of African descent. A double-blind-controlled study was used to evaluate the effect of UDCA on the managem...

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Bibliographic Details
Published in:Clinical and experimental gastroenterology 2019-07, Vol.12, p.349-354
Main Authors: Ughasoro, Maduka Donatus, Adimorah, Gilbert Nwadiaka, Chukwudi, Ndubuisi Kennedy, Nnakenyi, Ifeyinwa Dorothy, Iloh, Kenechukwu Kaosisochukwu, Udemba, Charles Ejike
Format: Article
Language:English
Subjects:
Acids
Babies
Bile
Blood groups
Caregivers
Gallbladder diseases
Gastroenterology
Hyperbilirubinemia
Jaundice
Light therapy
Liver
Medical research
Neonatal Hyperbilirubinemia
Neonatal jaundice
Newborn babies
Newborn infants
Original Research
Pediatrics
Phototherapy
Researchers
Sepsis
Skin
Studies
Teaching hospitals
Ursodeoxycholic acid
Ursodiol
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Summary:Phototherapy is paramount in the management of high total serum bilirubin (TSB). Whether its effectiveness can be improved with ursodeoxycholic acid (UDCA) has not been evaluated among newborns of African descent. A double-blind-controlled study was used to evaluate the effect of UDCA on the management of high TSB in neonates. Recruited neonates were categorized into the experimental group (given UDCA plus phototherapy) and the control group (phototherapy and plain syrup), and their TSB and conjugated bilirubin levels were measured. The data were analyzed using SPSS version 20. Statistical significance was set at a -value of
ISSN:1178-7023
1178-7023
DOI:10.2147/CEG.S207523