The role of single nucleotide polymorphisms of cytokine genes in viral infections

Gene polymorphisms result from evolutionary processes representing mutations that survive in the population with a frequency higher than 1%. The most investigated type of gene polymorphisms are single nucleotide polymorphisms (SNPs). The SNPs of IL-12B (rs 3212227) A/C among a population of kidney g...

Full description

Saved in:
Bibliographic Details
Published in:Archives of biological sciences 2014, Vol.66 (2), p.595-600
Main Authors: Cupic, Maja, Pravica, Vera, Lazarevic, Ivana, Banko, Ana, Karalic, Danijela, Tasic, Dijana, Jovanovic, Tanja
Format: Article
Language:English
Subjects:
cervical cancer
CMV
hepatitis C
HPV
IL-12B
IL-28B
kidney recipients
SNP
SVR
TNF-α
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gene polymorphisms result from evolutionary processes representing mutations that survive in the population with a frequency higher than 1%. The most investigated type of gene polymorphisms are single nucleotide polymorphisms (SNPs). The SNPs of IL-12B (rs 3212227) A/C among a population of kidney graft CMV-seropositive recipients have an impact on a clinical events in cytomegalovirus (CMV) disease. Constitutive -308 G/A TNF-? polymorphism (rs1800629) is related to the susceptibility of HR-HPV-associated cervical dysplasia and cancer. SNP located 3 kb upstream of the IL- 28B gene (rs12979860) seems to be the strongest host genetic predictor of sustained virologic response (SVR) in hepatitis C genotype 1 patients. It is very important to identify viral and host genetic markers that may facilitate the risk of developing viral disease or some viral-associated cancers. In addition, these markers could be useful in the choice of effective treatments and preventive strategies against virally induced infection.
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS1402595C