Development and Investigation of a Nanoemulgel Formulated from Tunisian Opuntia ficus-indica L. Seed Oil for Enhanced Wound Healing Activity

The aim of this study is to develop a nanoemulgel encapsulating a Tunisian Prickly Pear ( L.) seed oil (PPSO) to assess, for the first time, the in vivo efficacy of this nanoformulation on wound healing. Phytocompounds of this oil have been reported in the literature as having powerful pharmacologic...

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Published in:Gels 2024-09, Vol.10 (9), p.582
Main Authors: Bahloul, Badr, Ben Bnina, Enis, Dridi, Dorra, Bouhamed, Aya, Castillo Henríquez, Luis, Flamini, Guido, Vega-Baudrit, José Roberto
Format: Article
Language:English
Subjects:
advanced gels
Antioxidants
Bioavailability
Care and treatment
Drug delivery systems
Fatty acids
Fibroblasts
Flavonoids
gas chromatography
Growth factors
Hydrogels
In vivo methods and tests
Inflammation
Mupirocin
nanoemulsion
Nanoemulsions
Nanotechnology
Opuntia ficus-indica L
pharmaceutical nanotechnology
Photon correlation spectroscopy
phytotherapy
Polydispersity
Seeds
Skin
Surfactants
Vegetable oils
Wound healing
Wounds and injuries
Zeta potential
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Summary:The aim of this study is to develop a nanoemulgel encapsulating a Tunisian Prickly Pear ( L.) seed oil (PPSO) to assess, for the first time, the in vivo efficacy of this nanoformulation on wound healing. Phytocompounds of this oil have been reported in the literature as having powerful pharmacological activities. However, it remains poorly exploited due to low bioavailability. A nanoemulsion (NE) was designed by determining the required hydrophilic-lipophilic balance (HLB) and subsequently characterized. The mean droplet size was measured at 56.46 ± 1.12 nm, with a polydispersity index (PDI) of 0.23 ± 0.01 using dynamic light scattering. The zeta potential was -31.4 ± 1.4 mV, and the morphology was confirmed and assessed using transmission electron microscopy (TEM). These characteristics align with the typical properties of nanoemulsions. The gelification process resulted in the formation of a nanoemulgel from the optimum nanoemulsion. The high wound healing efficiency of the nanoemulgel was confirmed compared to that of a medicinally marketed cream. The outcomes of this research contribute valuable insights, for the first time, into the potential therapeutic applications of PPSO and its innovative pharmaceutical formulation for wound healing.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels10090582