Stability in the production and transport of 177Lu labelled PSMA

The prostate cancer is the second most prevalent disease among men in Brazil, moreover PSMA therapy could change this scenario and its perspectives. IPEN-CNEN is the Brazilian industrial radiopharmacy center that produces radiopharmaceuticals for therapy. The production of 177Lu-PSMA-617 was evaluat...

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Bibliographic Details
Published in:Brazilian Journal of Radiation Sciences 2021-03, Vol.9 (1)
Main Authors: Wieczorek Villas Boas, Cristian Antonio, Pereira Dias, Luís Alberto, Nakamura Matsuda, Margareth Mie, Bortoleti de Araújo, Elaine
Format: Article
Language:English
Subjects:
industrial radiopharmacy center
production of 177Lu-PSMA-617
radiopharmaceutical stability
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Summary:The prostate cancer is the second most prevalent disease among men in Brazil, moreover PSMA therapy could change this scenario and its perspectives. IPEN-CNEN is the Brazilian industrial radiopharmacy center that produces radiopharmaceuticals for therapy. The production of 177Lu-PSMA-617 was evaluated in batches until 37 GBq and showed that the combination of ascorbate buffer, adequate radioactive concentration and freezing promoted the stability of the radiopharmaceutical for 48 hours, enabling transport of 177Lu-PSMA-617 to distant regions of the country.
ISSN:2319-0612
2319-0612
DOI:10.15392/bjrs.v9i1.1619