The Correlation Between Essential Amino Acid Tryptophan, Lysine, Phenylalanine and Chemotherapy of Breast Cancer

To investigate the differences in serum tryptophan, lysine, and phenylalanine levels in breast cancer patients, the correlation between the three amino acids with the chemotherapy regimen, and their significance in the clinical diagnosis and treatment of breast cancer. Clinical data were collected f...

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Published in:Technology in cancer research & treatment 2024-01, Vol.23, p.15330338241286872
Main Authors: Lv, Yafeng, Yang, Xuan, Song, Ying, Yang, Dechun, Zheng, Kai, Zhou, Shaoqiang, Xie, Hanhui, Guo, Rong, Tang, Shicong
Format: Article
Language:English
Subjects:
Adult
Aged
Amino Acids, Essential - blood
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - blood
Breast Neoplasms - blood
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Case-Control Studies
Female
Humans
Lysine - blood
Middle Aged
Neoplasm Staging
Original
Phenylalanine - blood
Prognosis
Tandem Mass Spectrometry
Tryptophan - blood
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container_start_page 15330338241286872
container_title Technology in cancer research & treatment
container_volume 23
creator Lv, Yafeng
Yang, Xuan
Song, Ying
Yang, Dechun
Zheng, Kai
Zhou, Shaoqiang
Xie, Hanhui
Guo, Rong
Tang, Shicong
description To investigate the differences in serum tryptophan, lysine, and phenylalanine levels in breast cancer patients, the correlation between the three amino acids with the chemotherapy regimen, and their significance in the clinical diagnosis and treatment of breast cancer. Clinical data were collected from the Department of Breast Surgery at Yunnan Cancer Hospital, encompassing 216 cases from July to December 2020, including 91 healthy individuals, 38 with benign tumors, and 87 with cancer. Amino acid levels were measured using liquid chromatography-tandem mass spectrometry. Statistical analyses, such as the Kruskal-Wallis H-test and Wilcoxon test, were conducted to compare the levels of these amino acids across the healthy group, benign tumor group, and breast cancer group. The χ2 test and Fisher's exact probability method were employed to assess the relationship between amino acid levels and breast cancer stage, grade, and chemotherapy regimen. The results indicated that there were significant differences in serum lysine (H = 36.13, P  .05) levels across different conventional chemotherapy regimens among the breast cancer cases studied. Serum lysine and phenylalanine levels might serve as potential biomarkers for breast cancer, and the choice of chemotherapy regimen is unlikely to impact significant changes in these amino acid levels.
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Clinical data were collected from the Department of Breast Surgery at Yunnan Cancer Hospital, encompassing 216 cases from July to December 2020, including 91 healthy individuals, 38 with benign tumors, and 87 with cancer. Amino acid levels were measured using liquid chromatography-tandem mass spectrometry. Statistical analyses, such as the Kruskal-Wallis H-test and Wilcoxon test, were conducted to compare the levels of these amino acids across the healthy group, benign tumor group, and breast cancer group. The χ2 test and Fisher's exact probability method were employed to assess the relationship between amino acid levels and breast cancer stage, grade, and chemotherapy regimen. The results indicated that there were significant differences in serum lysine (H = 36.13, P &lt; .001) and phenylalanine (H = 34.03, P &lt; .001) levels among the three groups. However, tryptophan levels did not show statistically significant variances. Specifically, lysine and phenylalanine levels were significantly different when comparing the healthy group with the breast cancer group and the benign tumor group with the breast cancer group. These differences were not significant when comparing the healthy group with the benign tumor group. Furthermore, there were no statistically significant distinctions observed in lysine (F = 0.836, P &gt; .05) and phenylalanine (F = 1.466, P &gt; .05) levels across different conventional chemotherapy regimens among the breast cancer cases studied. 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treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lv, Yafeng</au><au>Yang, Xuan</au><au>Song, Ying</au><au>Yang, Dechun</au><au>Zheng, Kai</au><au>Zhou, Shaoqiang</au><au>Xie, Hanhui</au><au>Guo, Rong</au><au>Tang, Shicong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Correlation Between Essential Amino Acid Tryptophan, Lysine, Phenylalanine and Chemotherapy of Breast Cancer</atitle><jtitle>Technology in cancer research &amp; treatment</jtitle><addtitle>Technol Cancer Res Treat</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>23</volume><spage>15330338241286872</spage><pages>15330338241286872-</pages><issn>1533-0346</issn><issn>1533-0338</issn><eissn>1533-0338</eissn><abstract>To investigate the differences in serum tryptophan, lysine, and phenylalanine levels in breast cancer patients, the correlation between the three amino acids with the chemotherapy regimen, and their significance in the clinical diagnosis and treatment of breast cancer. 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Specifically, lysine and phenylalanine levels were significantly different when comparing the healthy group with the breast cancer group and the benign tumor group with the breast cancer group. These differences were not significant when comparing the healthy group with the benign tumor group. Furthermore, there were no statistically significant distinctions observed in lysine (F = 0.836, P &gt; .05) and phenylalanine (F = 1.466, P &gt; .05) levels across different conventional chemotherapy regimens among the breast cancer cases studied. Serum lysine and phenylalanine levels might serve as potential biomarkers for breast cancer, and the choice of chemotherapy regimen is unlikely to impact significant changes in these amino acid levels.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>39435510</pmid><doi>10.1177/15330338241286872</doi><orcidid>https://orcid.org/0000-0002-0666-5172</orcidid><oa>free_for_read</oa></addata></record>
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source SAGE Open Access; Publicly Available Content Database; PubMed Central
subjects Adult
Aged
Amino Acids, Essential - blood
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - blood
Breast Neoplasms - blood
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Case-Control Studies
Female
Humans
Lysine - blood
Middle Aged
Neoplasm Staging
Original
Phenylalanine - blood
Prognosis
Tandem Mass Spectrometry
Tryptophan - blood
title The Correlation Between Essential Amino Acid Tryptophan, Lysine, Phenylalanine and Chemotherapy of Breast Cancer
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