Efficacy of Stereotactic Body Radiotherapy versus Surgery for the Treatment 
of Early Non-small Cell Lung Cancer: A Meta-analysis

• Published in: Zhongguo fei ai za zhi 2020-12, Vol.23 (12), p.1066-1072
• Main Authors: Wu, Qiangbin, Gao, Wanpeng, Zhu, Jiawang, Wang, Qiang, Zhang, Wei
• Format: Article
• Language: Chinese
• Subjects: Ablation; Cancer therapies; Carcinoma, Non-Small-Cell Lung - radiotherapy; Carcinoma, Non-Small-Cell Lung - surgery; Comparative analysis; Humans; Lung cancer; lung neoplasms; Lung Neoplasms - mortality; Lung Neoplasms - radiotherapy; Lung Neoplasms - surgery; Meta-analysis; Older people; Radiation therapy; Radiosurgery - methods; Sensitivity analysis; stereotactic body radiotherapy; surgery; Survival analysis; Thoracic surgery; Treatment Outcome
• ISSN: 1009-3419; 1999-6187; 1999-6187
• DOI: 10.3779/j.issn.1009-3419.2020.101.50

To compare the clinical efficacy of stereotactic body radiotherapy (SBRT) versus surgery for early-stage non-small cell lung cancer through evidence based medicine analysis. A systematic search was performed in the PubMed, EMBASE, CNKI and Wan Fang databases to find studies published before June 2020. Two authors independently extracted the data and assessed the eligibility. All of the statistical analyses were performed using Stata 13.0. Subgroup analysis were performed according to the score matching study and operation type (lobectomy, segmentectomy and thoracoscopic assisted surgery). Finally, 14 articles were included, including 15,841 cases in SBRT group and 17,708 cases in operation group. 10 articles used propensity score matching methods for survival analysis. Thirteen were retrospective cohort studies and one was randomized controlled trial. The results of meta-analysis showed that the overall survival rate of the surgery group and the SBRT group was statistically significant. The overall survival r