Effects of Cognitive Behavioral Therapy for Depression and Anxiety, Response Rates and Adverse Events in Patients with Locoregional Advanced Nasopharyngeal Carcinoma

Purpose: This retrospective study investigated the effects of cognitive behavioral therapy (CBT) on depression, anxiety, response rates, and adverse events in patients with locoregional advanced nasopharyngeal carcinoma (NPC). Methods: A total of 269 patients with diagnosis of stage III-IVA NPC rece...

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Published in:Integrative cancer therapies 2021, Vol.20, p.15347354211006179
Main Authors: Liu, Feng, Fu, Sheng-nan, Chen, Yan-zhu, Yan, Ou-ying, Tong, Fei, Peng, Wang-lian, Zou, Ran, Wen, Min-ni, Jiang, Ling, Ma, Hong-zhi, He, Qian, Liu, Lin, Yang, Hui, Huang, Xu-fen, Han, Ya-qian, Wang, Hui, Liu, Xiao-hong
Format: Article
Language:English
Subjects:
Adverse events
Anxiety
Behavior modification
Chemoradiotherapy
Clinical trials
Cognitive ability
Cognitive behavioral therapy
Mental depression
Nasopharyngeal carcinoma
Patients
Radiation therapy
Response rates
Throat cancer
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Summary:Purpose: This retrospective study investigated the effects of cognitive behavioral therapy (CBT) on depression, anxiety, response rates, and adverse events in patients with locoregional advanced nasopharyngeal carcinoma (NPC). Methods: A total of 269 patients with diagnosis of stage III-IVA NPC received either CBT plus chemoradiotherapy (CBT group, n = 136) or treatment as usual (TAU) plus chemoradiotherapy (TAU group, n = 133). Patients in the CBT group received a series of 6 CBT sessions for 6 weeks during concurrent chemoradiotherapy. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale (HADS) score at baseline, the completion of radiotherapy, and 6, 12, and 24 months after radiotherapy. Response rates and adverse events were also evaluated. Results: Patients in the CBT group showed significantly less depression and anxiety than patients in the TAU group after the completion of radiotherapy (P 
ISSN:1534-7354
1552-695X
DOI:10.1177/15347354211006179