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Effects of Cognitive Behavioral Therapy for Depression and Anxiety, Response Rates and Adverse Events in Patients with Locoregional Advanced Nasopharyngeal Carcinoma
Purpose: This retrospective study investigated the effects of cognitive behavioral therapy (CBT) on depression, anxiety, response rates, and adverse events in patients with locoregional advanced nasopharyngeal carcinoma (NPC). Methods: A total of 269 patients with diagnosis of stage III-IVA NPC rece...
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Published in: | Integrative cancer therapies 2021, Vol.20, p.15347354211006179 |
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creator | Liu, Feng Fu, Sheng-nan Chen, Yan-zhu Yan, Ou-ying Tong, Fei Peng, Wang-lian Zou, Ran Wen, Min-ni Jiang, Ling Ma, Hong-zhi He, Qian Liu, Lin Yang, Hui Huang, Xu-fen Han, Ya-qian Wang, Hui Liu, Xiao-hong |
description | Purpose:
This retrospective study investigated the effects of cognitive behavioral therapy (CBT) on depression, anxiety, response rates, and adverse events in patients with locoregional advanced nasopharyngeal carcinoma (NPC).
Methods:
A total of 269 patients with diagnosis of stage III-IVA NPC received either CBT plus chemoradiotherapy (CBT group, n = 136) or treatment as usual (TAU) plus chemoradiotherapy (TAU group, n = 133). Patients in the CBT group received a series of 6 CBT sessions for 6 weeks during concurrent chemoradiotherapy. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale (HADS) score at baseline, the completion of radiotherapy, and 6, 12, and 24 months after radiotherapy. Response rates and adverse events were also evaluated.
Results:
Patients in the CBT group showed significantly less depression and anxiety than patients in the TAU group after the completion of radiotherapy (P |
doi_str_mv | 10.1177/15347354211006179 |
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fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_47fba9a1c507457cb4af831f59f61032</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_15347354211006179</sage_id><doaj_id>oai_doaj_org_article_47fba9a1c507457cb4af831f59f61032</doaj_id><sourcerecordid>2613285836</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-88b5f47813a8786f686f07c52dbce17f2afdf72aa0662f14e81d41ff02318a93</originalsourceid><addsrcrecordid>eNp1kktvEzEQx1cIRB_wAbggS1xJ8XPtXJBKCFApAlTlwG018Y43jhJ7sTeh-UB8T5ymFCrEwfJo5j-_eWiq6gWjF4xp_YYpIbVQkjNGac30-FF1ypTio3qsvj0-2EKODoKT6iznFaWc0Vo9rU6E0EYarU6rn1Pn0A6ZREcmsQt-8Dsk73AJOx8TrMl8iQn6PXExkffYJ8zZx0AgtOQy3Hgc9q_JNeY-hozkGgbMx1i7w1Q80x2GQveBfIXB39o__LAks2hjwq6gSo0ihmCxJZ8hx34JaR86LP4JJOtD3MCz6omDdcbnd_95Nf8wnU8-jWZfPl5NLmcjqwQfRsYslJPaMAFGm9rV5VFtFW8XFpl2HFzrNAegdc0dk2hYK5lzlAtmYCzOq6sjto2wavrkN6WVJoJvbh0xdQ2kwds1NlK7BYyBWUW1VNouJDgjmFNjVzMqeGG9PbL67WKDrS2jl3U-gD6MBL9surhrDOWUSlYAr-4AKX7fYh6aVdymsq7c8JoJbpQRdVGxo8qmmHNCd1-B0eZwJM0_R1JyXv7d2n3G76sogoujIEOHf8r-n_gLXzPHlQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2613285836</pqid></control><display><type>article</type><title>Effects of Cognitive Behavioral Therapy for Depression and Anxiety, Response Rates and Adverse Events in Patients with Locoregional Advanced Nasopharyngeal Carcinoma</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>PubMed Central(OpenAccess)</source><source>SAGE Open Access Journals</source><creator>Liu, Feng ; Fu, Sheng-nan ; Chen, Yan-zhu ; Yan, Ou-ying ; Tong, Fei ; Peng, Wang-lian ; Zou, Ran ; Wen, Min-ni ; Jiang, Ling ; Ma, Hong-zhi ; He, Qian ; Liu, Lin ; Yang, Hui ; Huang, Xu-fen ; Han, Ya-qian ; Wang, Hui ; Liu, Xiao-hong</creator><creatorcontrib>Liu, Feng ; Fu, Sheng-nan ; Chen, Yan-zhu ; Yan, Ou-ying ; Tong, Fei ; Peng, Wang-lian ; Zou, Ran ; Wen, Min-ni ; Jiang, Ling ; Ma, Hong-zhi ; He, Qian ; Liu, Lin ; Yang, Hui ; Huang, Xu-fen ; Han, Ya-qian ; Wang, Hui ; Liu, Xiao-hong</creatorcontrib><description>Purpose:
This retrospective study investigated the effects of cognitive behavioral therapy (CBT) on depression, anxiety, response rates, and adverse events in patients with locoregional advanced nasopharyngeal carcinoma (NPC).
Methods:
A total of 269 patients with diagnosis of stage III-IVA NPC received either CBT plus chemoradiotherapy (CBT group, n = 136) or treatment as usual (TAU) plus chemoradiotherapy (TAU group, n = 133). Patients in the CBT group received a series of 6 CBT sessions for 6 weeks during concurrent chemoradiotherapy. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale (HADS) score at baseline, the completion of radiotherapy, and 6, 12, and 24 months after radiotherapy. Response rates and adverse events were also evaluated.
Results:
Patients in the CBT group showed significantly less depression and anxiety than patients in the TAU group after the completion of radiotherapy (P < .05). Complete response rates were 99.3% (135/136) and 92.5% (123/133) in the CBT group and TAU group with a small effect size (Phi coefficient = .171), respectively (P = .005). Compared with the TAU group, the CBT group showed a significantly lower incidence of acute adverse events and late toxic effects.
Conclusions:
The addition of CBT to chemoradiotherapy significantly reduced depressive and anxiety symptoms. CBT combined with chemoradiotherapy is associated with improved response rates, with reduced incidence of toxic effects in patients with locoregional advanced NPC. Based on this study, we registered a randomized controlled clinical trials to better define the role of CBT in patients with locoregional advanced NPC (Registration number: ChiCTR2000034701).</description><identifier>ISSN: 1534-7354</identifier><identifier>EISSN: 1552-695X</identifier><identifier>DOI: 10.1177/15347354211006179</identifier><identifier>PMID: 33784875</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adverse events ; Anxiety ; Behavior modification ; Chemoradiotherapy ; Clinical trials ; Cognitive ability ; Cognitive behavioral therapy ; Mental depression ; Nasopharyngeal carcinoma ; Patients ; Radiation therapy ; Response rates ; Throat cancer</subject><ispartof>Integrative cancer therapies, 2021, Vol.20, p.15347354211006179</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021 2021 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-88b5f47813a8786f686f07c52dbce17f2afdf72aa0662f14e81d41ff02318a93</citedby><cites>FETCH-LOGICAL-c532t-88b5f47813a8786f686f07c52dbce17f2afdf72aa0662f14e81d41ff02318a93</cites><orcidid>0000-0002-0949-3679</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020041/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2613285836?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,21966,25753,27853,27923,27924,27925,37012,44590,44945,45333,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33784875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Fu, Sheng-nan</creatorcontrib><creatorcontrib>Chen, Yan-zhu</creatorcontrib><creatorcontrib>Yan, Ou-ying</creatorcontrib><creatorcontrib>Tong, Fei</creatorcontrib><creatorcontrib>Peng, Wang-lian</creatorcontrib><creatorcontrib>Zou, Ran</creatorcontrib><creatorcontrib>Wen, Min-ni</creatorcontrib><creatorcontrib>Jiang, Ling</creatorcontrib><creatorcontrib>Ma, Hong-zhi</creatorcontrib><creatorcontrib>He, Qian</creatorcontrib><creatorcontrib>Liu, Lin</creatorcontrib><creatorcontrib>Yang, Hui</creatorcontrib><creatorcontrib>Huang, Xu-fen</creatorcontrib><creatorcontrib>Han, Ya-qian</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Liu, Xiao-hong</creatorcontrib><title>Effects of Cognitive Behavioral Therapy for Depression and Anxiety, Response Rates and Adverse Events in Patients with Locoregional Advanced Nasopharyngeal Carcinoma</title><title>Integrative cancer therapies</title><addtitle>Integr Cancer Ther</addtitle><description>Purpose:
This retrospective study investigated the effects of cognitive behavioral therapy (CBT) on depression, anxiety, response rates, and adverse events in patients with locoregional advanced nasopharyngeal carcinoma (NPC).
Methods:
A total of 269 patients with diagnosis of stage III-IVA NPC received either CBT plus chemoradiotherapy (CBT group, n = 136) or treatment as usual (TAU) plus chemoradiotherapy (TAU group, n = 133). Patients in the CBT group received a series of 6 CBT sessions for 6 weeks during concurrent chemoradiotherapy. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale (HADS) score at baseline, the completion of radiotherapy, and 6, 12, and 24 months after radiotherapy. Response rates and adverse events were also evaluated.
Results:
Patients in the CBT group showed significantly less depression and anxiety than patients in the TAU group after the completion of radiotherapy (P < .05). Complete response rates were 99.3% (135/136) and 92.5% (123/133) in the CBT group and TAU group with a small effect size (Phi coefficient = .171), respectively (P = .005). Compared with the TAU group, the CBT group showed a significantly lower incidence of acute adverse events and late toxic effects.
Conclusions:
The addition of CBT to chemoradiotherapy significantly reduced depressive and anxiety symptoms. CBT combined with chemoradiotherapy is associated with improved response rates, with reduced incidence of toxic effects in patients with locoregional advanced NPC. Based on this study, we registered a randomized controlled clinical trials to better define the role of CBT in patients with locoregional advanced NPC (Registration number: ChiCTR2000034701).</description><subject>Adverse events</subject><subject>Anxiety</subject><subject>Behavior modification</subject><subject>Chemoradiotherapy</subject><subject>Clinical trials</subject><subject>Cognitive ability</subject><subject>Cognitive behavioral therapy</subject><subject>Mental depression</subject><subject>Nasopharyngeal carcinoma</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Response rates</subject><subject>Throat cancer</subject><issn>1534-7354</issn><issn>1552-695X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kktvEzEQx1cIRB_wAbggS1xJ8XPtXJBKCFApAlTlwG018Y43jhJ7sTeh-UB8T5ymFCrEwfJo5j-_eWiq6gWjF4xp_YYpIbVQkjNGac30-FF1ypTio3qsvj0-2EKODoKT6iznFaWc0Vo9rU6E0EYarU6rn1Pn0A6ZREcmsQt-8Dsk73AJOx8TrMl8iQn6PXExkffYJ8zZx0AgtOQy3Hgc9q_JNeY-hozkGgbMx1i7w1Q80x2GQveBfIXB39o__LAks2hjwq6gSo0ihmCxJZ8hx34JaR86LP4JJOtD3MCz6omDdcbnd_95Nf8wnU8-jWZfPl5NLmcjqwQfRsYslJPaMAFGm9rV5VFtFW8XFpl2HFzrNAegdc0dk2hYK5lzlAtmYCzOq6sjto2wavrkN6WVJoJvbh0xdQ2kwds1NlK7BYyBWUW1VNouJDgjmFNjVzMqeGG9PbL67WKDrS2jl3U-gD6MBL9surhrDOWUSlYAr-4AKX7fYh6aVdymsq7c8JoJbpQRdVGxo8qmmHNCd1-B0eZwJM0_R1JyXv7d2n3G76sogoujIEOHf8r-n_gLXzPHlQ</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Liu, Feng</creator><creator>Fu, Sheng-nan</creator><creator>Chen, Yan-zhu</creator><creator>Yan, Ou-ying</creator><creator>Tong, Fei</creator><creator>Peng, Wang-lian</creator><creator>Zou, Ran</creator><creator>Wen, Min-ni</creator><creator>Jiang, Ling</creator><creator>Ma, Hong-zhi</creator><creator>He, Qian</creator><creator>Liu, Lin</creator><creator>Yang, Hui</creator><creator>Huang, Xu-fen</creator><creator>Han, Ya-qian</creator><creator>Wang, Hui</creator><creator>Liu, Xiao-hong</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><general>SAGE Publishing</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0949-3679</orcidid></search><sort><creationdate>2021</creationdate><title>Effects of Cognitive Behavioral Therapy for Depression and Anxiety, Response Rates and Adverse Events in Patients with Locoregional Advanced Nasopharyngeal Carcinoma</title><author>Liu, Feng ; Fu, Sheng-nan ; Chen, Yan-zhu ; Yan, Ou-ying ; Tong, Fei ; Peng, Wang-lian ; Zou, Ran ; Wen, Min-ni ; Jiang, Ling ; Ma, Hong-zhi ; He, Qian ; Liu, Lin ; Yang, Hui ; Huang, Xu-fen ; Han, Ya-qian ; Wang, Hui ; Liu, Xiao-hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-88b5f47813a8786f686f07c52dbce17f2afdf72aa0662f14e81d41ff02318a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adverse events</topic><topic>Anxiety</topic><topic>Behavior modification</topic><topic>Chemoradiotherapy</topic><topic>Clinical trials</topic><topic>Cognitive ability</topic><topic>Cognitive behavioral therapy</topic><topic>Mental depression</topic><topic>Nasopharyngeal carcinoma</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Response rates</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Fu, Sheng-nan</creatorcontrib><creatorcontrib>Chen, Yan-zhu</creatorcontrib><creatorcontrib>Yan, Ou-ying</creatorcontrib><creatorcontrib>Tong, Fei</creatorcontrib><creatorcontrib>Peng, Wang-lian</creatorcontrib><creatorcontrib>Zou, Ran</creatorcontrib><creatorcontrib>Wen, Min-ni</creatorcontrib><creatorcontrib>Jiang, Ling</creatorcontrib><creatorcontrib>Ma, Hong-zhi</creatorcontrib><creatorcontrib>He, Qian</creatorcontrib><creatorcontrib>Liu, Lin</creatorcontrib><creatorcontrib>Yang, Hui</creatorcontrib><creatorcontrib>Huang, Xu-fen</creatorcontrib><creatorcontrib>Han, Ya-qian</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Liu, Xiao-hong</creatorcontrib><collection>SAGE Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Integrative cancer therapies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Feng</au><au>Fu, Sheng-nan</au><au>Chen, Yan-zhu</au><au>Yan, Ou-ying</au><au>Tong, Fei</au><au>Peng, Wang-lian</au><au>Zou, Ran</au><au>Wen, Min-ni</au><au>Jiang, Ling</au><au>Ma, Hong-zhi</au><au>He, Qian</au><au>Liu, Lin</au><au>Yang, Hui</au><au>Huang, Xu-fen</au><au>Han, Ya-qian</au><au>Wang, Hui</au><au>Liu, Xiao-hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Cognitive Behavioral Therapy for Depression and Anxiety, Response Rates and Adverse Events in Patients with Locoregional Advanced Nasopharyngeal Carcinoma</atitle><jtitle>Integrative cancer therapies</jtitle><addtitle>Integr Cancer Ther</addtitle><date>2021</date><risdate>2021</risdate><volume>20</volume><spage>15347354211006179</spage><pages>15347354211006179-</pages><issn>1534-7354</issn><eissn>1552-695X</eissn><abstract>Purpose:
This retrospective study investigated the effects of cognitive behavioral therapy (CBT) on depression, anxiety, response rates, and adverse events in patients with locoregional advanced nasopharyngeal carcinoma (NPC).
Methods:
A total of 269 patients with diagnosis of stage III-IVA NPC received either CBT plus chemoradiotherapy (CBT group, n = 136) or treatment as usual (TAU) plus chemoradiotherapy (TAU group, n = 133). Patients in the CBT group received a series of 6 CBT sessions for 6 weeks during concurrent chemoradiotherapy. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale (HADS) score at baseline, the completion of radiotherapy, and 6, 12, and 24 months after radiotherapy. Response rates and adverse events were also evaluated.
Results:
Patients in the CBT group showed significantly less depression and anxiety than patients in the TAU group after the completion of radiotherapy (P < .05). Complete response rates were 99.3% (135/136) and 92.5% (123/133) in the CBT group and TAU group with a small effect size (Phi coefficient = .171), respectively (P = .005). Compared with the TAU group, the CBT group showed a significantly lower incidence of acute adverse events and late toxic effects.
Conclusions:
The addition of CBT to chemoradiotherapy significantly reduced depressive and anxiety symptoms. CBT combined with chemoradiotherapy is associated with improved response rates, with reduced incidence of toxic effects in patients with locoregional advanced NPC. Based on this study, we registered a randomized controlled clinical trials to better define the role of CBT in patients with locoregional advanced NPC (Registration number: ChiCTR2000034701).</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>33784875</pmid><doi>10.1177/15347354211006179</doi><orcidid>https://orcid.org/0000-0002-0949-3679</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adverse events Anxiety Behavior modification Chemoradiotherapy Clinical trials Cognitive ability Cognitive behavioral therapy Mental depression Nasopharyngeal carcinoma Patients Radiation therapy Response rates Throat cancer |
title | Effects of Cognitive Behavioral Therapy for Depression and Anxiety, Response Rates and Adverse Events in Patients with Locoregional Advanced Nasopharyngeal Carcinoma |
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