A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine

We have developed a new method to prepare 4-acetoxy substituted 5(4 )-oxazolones by direct oxidation of -benzoyl amino-acids using hypervalent iodine. The method is efficient, economical and easy to perform for the synthesis of quaternary substituted amino acid derivatives. We used online FTIR monit...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-07, Vol.22 (7), p.1102
Main Authors: Wen, Gang, Zhang, Wen-Xuan, Wu, Song
Format: Article
Language:English
Subjects:
4-acetoxyl 5(4H)-oxazolones
Acids
Amino Acids - chemistry
Catalysis
hypervalent iodine
Iodine
Iodine - chemistry
Letter
Molecular Structure
N-benzoyl amino-acid
online FTIR
Oxazolone - chemistry
Oxidation
Oxidation-Reduction
Reaction mechanisms
Substitutes
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Summary:We have developed a new method to prepare 4-acetoxy substituted 5(4 )-oxazolones by direct oxidation of -benzoyl amino-acids using hypervalent iodine. The method is efficient, economical and easy to perform for the synthesis of quaternary substituted amino acid derivatives. We used online FTIR monitoring techniques to analyze the reaction, and gave a plausible reaction mechanism.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22071102