Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization

The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. ADAMTS proteins have...

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Bibliographic Details
Published in:BMC evolutionary biology 2005-02, Vol.5 (1), p.11-11, Article 11
Main Authors: Nicholson, Ainsley C, Malik, Shehre-Banoo, Logsdon, Jr, John M, Van Meir, Erwin G
Format: Article
Language:English
Subjects:
ADAM Proteins - chemistry
ADAM Proteins - metabolism
Amino Acid Motifs
Animals
Caenorhabditis
Caenorhabditis elegans
Chordata
Ciona
Ciona intestinalis
Computer Simulation
Drosophila
Evolution, Molecular
Expressed Sequence Tags
Fugu
Gene Duplication
Genome
Humans
Introns
Models, Genetic
Mus
Phylogeny
Protein Structure, Tertiary
Software
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Summary:The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. ADAMTS proteins have recently gained attention with the discovery of their role in a variety of diseases, including tissue and blood disorders, cancer, osteoarthritis, Alzheimer's and the genetic syndromes Weill-Marchesani syndrome (ADAMTS10), thrombotic thrombocytopenic purpura (ADAMTS13), and Ehlers-Danlos syndrome type VIIC (ADAMTS2) in humans and belted white-spotting mutation in mice (ADAMTS20). Phylogenetic analysis and comparison of the exon/intron organization of vertebrate (Homo, Mus, Fugu), chordate (Ciona) and invertebrate (Drosophila and Caenorhabditis) ADAMTS homologs has elucidated the evolutionary relationships of this important gene family, which comprises 19 members in humans. The evolutionary history of ADAMTS genes in vertebrate genomes has been marked by rampant gene duplication, including a retrotransposition that gave rise to a distinct ADAMTS subfamily (ADAMTS1, -4, -5, -8, -15) that may have distinct aggrecanase and angiogenesis functions.
ISSN:1471-2148
1471-2148
DOI:10.1186/1471-2148-5-11