Patients with primary sclerosing cholangitis require more sedation during endoscopic retrograde cholangiography

Abstract Background and study aims  Patients with primary sclerosing cholangitis (PSC) require repeated endoscopic retrograde cholangiography (ERC). Our aim was to evaluate whether patients with PSC require higher doses of sedation during ERC. Patients and methods  We retrospectively analyzed all pa...

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Published in:Endoscopy International Open 2017-04, Vol.5 (4), p.E315-E320
Main Authors: Keil, Carsten, Aguirre Dávila, Lukas, Framke, Theodor, Lenzen, Henrike, Manns, Michael P., Lankisch, Tim O., Voigtländer, Torsten
Format: Article
Language:English
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Summary:Abstract Background and study aims  Patients with primary sclerosing cholangitis (PSC) require repeated endoscopic retrograde cholangiography (ERC). Our aim was to evaluate whether patients with PSC require higher doses of sedation during ERC. Patients and methods  We retrospectively analyzed all patients undergoing ERC from 2006 to 2013 who received conscious sedation with propofol and midazolam. The duration of the intervention and a potential progression of propofol consumption or intervention time by visit number were analyzed. Univariable and multivariable analyses were performed to identify independent factors which influence propofol consumption. Results  A total of 2962 ERC procedures were performed in 1211 patients. Patients with PSC (n = 157) underwent 461 ERC procedures whereas patients without PSC (n = 1054) had 2501 ERC examinations. The total median propofol dose was 450 mg (290 – 630 mg) for patients with PSC and 300 mg (200 – 450 mg) for the non-PSC group ( P  
ISSN:2364-3722
2196-9736
DOI:10.1055/s-0043-104858