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Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD
Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with heterogeneous symptomatology. Arguably, the most pervasive shortfall of ASD are the deficits in sociability and the animal models of the disorder are expected to exhibit such impairments. The most widely utilized behavior...
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| Published in: | Behavioral and brain functions 2024-09, Vol.20 (1), p.24-6, Article 24 |
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| creator | Szabó, Jakub Renczés, Emese Borbélyová, Veronika Ostatníková, Daniela Celec, Peter |
| description | Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with heterogeneous symptomatology. Arguably, the most pervasive shortfall of ASD are the deficits in sociability and the animal models of the disorder are expected to exhibit such impairments. The most widely utilized behavioral task for assessing sociability in rodents is the Three-Chamber Social Interaction Test (SIT). However, SIT has been yielding inconsistent results in social interaction behavior across different rodent models of ASD, which could be pointing to the suboptimal methodology of the task. Here, we compared social behavior assessed in SIT and in another prominent sociability behavioral assay, Reciprocal Interaction Test (RCI), in a SH3 and multiple ankyrin repeated domains 3 (SHANK3) mouse model of ASD. Head-to-head comparison showed no association (p = 0.15, 0.25, 0.43) and a fixed bias (p = 0.01, |
| doi_str_mv | 10.1186/s12993-024-00251-0 |
| format | article |
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mice. Adult Shank3B
mice of both sexes displayed normative sociability in SIT when compared to the WT controls (p = 0.74) but exhibited less than half of social interaction (p < 0.001) and almost three times more social disinterest (p < 0.001) when compared to WT mice in RCI. At least in the Shank3B
mouse model of ASD, we presume RCI could be a preferable way of assessing social interaction compared to SIT. Considering the variability of animal models of ASD and the wide palette of tools available for the assessment of their behavior, a consensus approach would be needed for observational and interventional analyses.</description><identifier>ISSN: 1744-9081</identifier><identifier>EISSN: 1744-9081</identifier><identifier>DOI: 10.1186/s12993-024-00251-0</identifier><identifier>PMID: 39342245</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Animals ; Autism ; Autism Spectrum Disorder - genetics ; Autism Spectrum Disorder - psychology ; Behavior, Animal - physiology ; Behavioral phenotyping ; Disease Models, Animal ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins - genetics ; Nerve Tissue Proteins - genetics ; Phelan-McDermid syndrome ; Social Behavior ; Social Interaction</subject><ispartof>Behavioral and brain functions, 2024-09, Vol.20 (1), p.24-6, Article 24</ispartof><rights>2024. The Author(s).</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c407t-a562e0b998fc75b093c6b691caec951a8bb632dc249a1e7c12e4a828903ccb183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439274/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439274/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,36992,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39342245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szabó, Jakub</creatorcontrib><creatorcontrib>Renczés, Emese</creatorcontrib><creatorcontrib>Borbélyová, Veronika</creatorcontrib><creatorcontrib>Ostatníková, Daniela</creatorcontrib><creatorcontrib>Celec, Peter</creatorcontrib><title>Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD</title><title>Behavioral and brain functions</title><addtitle>Behav Brain Funct</addtitle><description>Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with heterogeneous symptomatology. Arguably, the most pervasive shortfall of ASD are the deficits in sociability and the animal models of the disorder are expected to exhibit such impairments. The most widely utilized behavioral task for assessing sociability in rodents is the Three-Chamber Social Interaction Test (SIT). However, SIT has been yielding inconsistent results in social interaction behavior across different rodent models of ASD, which could be pointing to the suboptimal methodology of the task. Here, we compared social behavior assessed in SIT and in another prominent sociability behavioral assay, Reciprocal Interaction Test (RCI), in a SH3 and multiple ankyrin repeated domains 3 (SHANK3) mouse model of ASD. Head-to-head comparison showed no association (p = 0.15, 0.25, 0.43) and a fixed bias (p = 0.01, < 0.001, < 0.001) in sociability assessment between the behavioral assays in both wild-type (WT) controls and Shank3B
mice. Adult Shank3B
mice of both sexes displayed normative sociability in SIT when compared to the WT controls (p = 0.74) but exhibited less than half of social interaction (p < 0.001) and almost three times more social disinterest (p < 0.001) when compared to WT mice in RCI. At least in the Shank3B
mouse model of ASD, we presume RCI could be a preferable way of assessing social interaction compared to SIT. Considering the variability of animal models of ASD and the wide palette of tools available for the assessment of their behavior, a consensus approach would be needed for observational and interventional analyses.</description><subject>Animals</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - genetics</subject><subject>Autism Spectrum Disorder - psychology</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral phenotyping</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Microfilament Proteins - genetics</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Phelan-McDermid syndrome</subject><subject>Social Behavior</subject><subject>Social Interaction</subject><issn>1744-9081</issn><issn>1744-9081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptksFu1DAQhiMEoqXwAhyQj1wCHttJ7BNaLbSsVAmJLmdr7Ex2XSXxYmcr9RF4a7K7pWolLvZo5p9vRqO_KN4D_wSg688ZhDGy5EKVnIsKSv6iOIdGqdJwDS-fxGfFm5xvOZdaCfG6OJNGzoGqzos_i5wp5zBuWI4-oAt9mO7Z_piZtsTW20RULrc4OErs5qDp2WqcKKGfQhzZmvLEcGyP6p_kwy5F_z9NGBmyDY00Bc-GuM80vy31LHZscfP1bfGqwz7Tu4f_ovh1-W29_F5e_7haLRfXpVe8mUqsakHcGaM731SOG-lrVxvwSN5UgNq5WorWC2UQqPEgSKEW2nDpvQMtL4rVidtGvLW7FAZM9zZisMdETBuLaV6xJ6u0qE3bNp0iqaCujBbofG1Q61p2vppZX06s3d4N1Hoap4T9M-jzyhi2dhPvLICSRjRqJnx8IKT4ez-fyQ4he-p7HGk-kZUA3IACfRgmTlKfYs6Jusc5wO3BEPZkCDsbwh4NYfnc9OHpho8t_xwg_wIkkLLz</recordid><startdate>20240928</startdate><enddate>20240928</enddate><creator>Szabó, Jakub</creator><creator>Renczés, Emese</creator><creator>Borbélyová, Veronika</creator><creator>Ostatníková, Daniela</creator><creator>Celec, Peter</creator><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240928</creationdate><title>Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD</title><author>Szabó, Jakub ; Renczés, Emese ; Borbélyová, Veronika ; Ostatníková, Daniela ; Celec, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-a562e0b998fc75b093c6b691caec951a8bb632dc249a1e7c12e4a828903ccb183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Autism</topic><topic>Autism Spectrum Disorder - genetics</topic><topic>Autism Spectrum Disorder - psychology</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral phenotyping</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Microfilament Proteins - genetics</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Phelan-McDermid syndrome</topic><topic>Social Behavior</topic><topic>Social Interaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szabó, Jakub</creatorcontrib><creatorcontrib>Renczés, Emese</creatorcontrib><creatorcontrib>Borbélyová, Veronika</creatorcontrib><creatorcontrib>Ostatníková, Daniela</creatorcontrib><creatorcontrib>Celec, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Behavioral and brain functions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szabó, Jakub</au><au>Renczés, Emese</au><au>Borbélyová, Veronika</au><au>Ostatníková, Daniela</au><au>Celec, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD</atitle><jtitle>Behavioral and brain functions</jtitle><addtitle>Behav Brain Funct</addtitle><date>2024-09-28</date><risdate>2024</risdate><volume>20</volume><issue>1</issue><spage>24</spage><epage>6</epage><pages>24-6</pages><artnum>24</artnum><issn>1744-9081</issn><eissn>1744-9081</eissn><abstract>Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with heterogeneous symptomatology. Arguably, the most pervasive shortfall of ASD are the deficits in sociability and the animal models of the disorder are expected to exhibit such impairments. The most widely utilized behavioral task for assessing sociability in rodents is the Three-Chamber Social Interaction Test (SIT). However, SIT has been yielding inconsistent results in social interaction behavior across different rodent models of ASD, which could be pointing to the suboptimal methodology of the task. Here, we compared social behavior assessed in SIT and in another prominent sociability behavioral assay, Reciprocal Interaction Test (RCI), in a SH3 and multiple ankyrin repeated domains 3 (SHANK3) mouse model of ASD. Head-to-head comparison showed no association (p = 0.15, 0.25, 0.43) and a fixed bias (p = 0.01, < 0.001, < 0.001) in sociability assessment between the behavioral assays in both wild-type (WT) controls and Shank3B
mice. Adult Shank3B
mice of both sexes displayed normative sociability in SIT when compared to the WT controls (p = 0.74) but exhibited less than half of social interaction (p < 0.001) and almost three times more social disinterest (p < 0.001) when compared to WT mice in RCI. At least in the Shank3B
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| subjects | Animals Autism Autism Spectrum Disorder - genetics Autism Spectrum Disorder - psychology Behavior, Animal - physiology Behavioral phenotyping Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Microfilament Proteins - genetics Nerve Tissue Proteins - genetics Phelan-McDermid syndrome Social Behavior Social Interaction |
| title | Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD |
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