The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to...

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Bibliographic Details
Published in:Biomedicines 2022-08, Vol.10 (8), p.1878
Main Authors: Lauer, Henrik, Prahm, Cosima, Thiel, Johannes Tobias, Kolbenschlag, Jonas, Daigeler, Adrien, Hercher, David, Heinzel, Johannes C
Format: Article
Language:English
Subjects:
Allografts
Animal models
Grasping
grasping test
Injuries
Median nerve
Medical research
Medicine, Experimental
Meta-analysis
nerve crush
nerve repair
nerve transection
Patient outcomes
Peripheral nerve diseases
Peripheral nerves
rat
Recovery of function
Systematic Review
Citations: Items that this one cites
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Summary:The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10081878