HPV and cofactors for invasive cervical cancer in Morocco: a multicentre case-control study

• Published in: BMC cancer 2017-06, Vol.17 (1), p.435-435, Article 435
• Main Authors: Berraho, Mohamed, Amarti-Riffi, Afaf, El-Mzibri, Mohammed, Bezad, Rachid, Benjaafar, Noureddine, Benideer, Abdelatif, Matar, Noureddine, Qmichou, Zinab, Abda, Naima, Attaleb, Mohammed, Znati, Kaoutar, El Fatemi, Hind, Bendahhou, Karima, Obtel, Majdouline, Filali Adib, Abdelhai, Mathoulin-Pelissier, Simone, Nejjari, Chakib
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Analysis; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - virology; Case-Control Studies; Case-control study; Cellular biology; Cervical cancer; Cervix; Chlamydia; Cofactors; Complications and side effects; Deoxyribonucleic acid; Determinants; Development and progression; DNA; DNA, Viral - isolation & purification; Female; Gynecology; Health aspects; Health risk assessment; Hospitals; Hpv; Human papillomavirus; Human papillomavirus 16 - isolation & purification; Human papillomavirus 16 - pathogenicity; Humans; Infections; Invasiveness; Menstruation; Middle Aged; Morocco; Morocco - epidemiology; Mortality; Multivariate analysis; Papillomavirus infections; Papillomavirus Infections - epidemiology; Papillomavirus Infections - pathology; Papillomavirus Infections - virology; Polymerase chain reaction; Population; Regression analysis; Risk Factors; Sexual intercourse; Sexual partners; Sexually Transmitted Diseases - epidemiology; Sexually Transmitted Diseases - pathology; Sexually Transmitted Diseases - virology; Studies; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - virology; Womens health
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-017-3425-z

Limited national information is available in Morocco on the prevalence and distribution of HPV-sub-types of cervical cancer and the role of other risk factors. The aim was to determine the frequency of HPV-sub-types of cervical cancer in Morocco and investigate risk factors for this disease. Between November 2009 and April 2012 a multicentre case-control study was carried out. A total of 144 cases of cervical cancer and 288 age-matched controls were included. Odds-ratios and corresponding confidence-intervals were computed by conditional logistic regression models. Current HPV infection was detected in 92.5% of cases and 13.9% of controls. HPV16 was the most common type for both cases and controls. Very strong associations between HPV-sub-types and cervical cancer were observed: total-HPV (OR = 39), HPV16 (OR = 49), HPV18 (OR = 31), and multiple infections (OR = 13). Education, high parity, sexual intercourse during menstruation, history of sexually transmitted infections, and husband's multiple sexual partners were also significantly associated with cervical cancer in the multivariate analysis. Our results could be used to establish a primary prevention program and to prioritize limited screening to women who have specific characteristics that may put them at an increased risk of cervical cancer.