MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis

Objective The methionine synthase reductase (MTRR) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. Methods We pe...

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Bibliographic Details
Published in:Journal of international medical research 2022-05, Vol.50 (5), p.3000605221097486-3000605221097486
Main Authors: Zhong, Guping, Luo, Xiaojin, Li, Ji, Liao, Yuanhang, Gui, Guan, Sheng, Jianwen
Format: Article
Language:English
Subjects:
Case-Control Studies
Ferredoxin-NADP Reductase
Gastric cancer
Genetic Predisposition to Disease
Humans
Meta Analysis
Polymorphism
Polymorphism, Single Nucleotide
Risk Factors
Stomach Neoplasms - genetics
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Summary:Objective The methionine synthase reductase (MTRR) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but the results have been inconsistent. Methods We performed a comprehensive and systematic search of PubMed, Google Scholar, MEDLINE, Science Direct, Scopus, CNKI, and Web of Science. Five studies were included in this meta-analysis to determine whether MTRR rs1532268 polymorphism contributes to the risk of GC. Results Pooled data indicated that the MTRR rs1532268 polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 1.01–1.29) and dominant model (OR = 1.14, 95% CI = 1.00–1.30). In the analysis stratified by ethnicity, no relationship was found in Whites or Asians. Conclusion Our meta-analysis suggests a positive correlation between MTRR rs1532268 polymorphism and GC development.
ISSN:0300-0605
1473-2300
DOI:10.1177/03000605221097486