Efficacy of Radial Endobronchial Ultrasound (R-EBUS) guided transbronchial cryobiopsy for peripheral pulmonary lesions (PPL...s): A systematic review and meta-analysis

Transbronchial lung cryobiopsy (TBLC) is frequently described for the diagnosis of diffuse parenchymal lung diseases (DPLD). A few studies have reported transbronchial cryobiopsy for the diagnosis of peripheral pulmonary lesions (PPL...s). We aimed to study the utility and safety of transbronchial c...

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Published in:Pulmonology 2023-01, Vol.29 (1), p.50-64
Main Authors: Sryma, P.B., Mittal, S., Madan, N.K., Tiwari, P., Hadda, V., Mohan, A., Guleria, R., Madan, K.
Format: Article
Language:English
Subjects:
Biopsy
Bronchoscopy
Cryobiopsy
Endobronchial ultrasound
Humans
Lung - diagnostic imaging
Lung - pathology
Lung cancer
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - pathology
Lung Neoplasms - pathology
Lung nodule
Peripheral pulmonary lesion
Pneumothorax - etiology
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Summary:Transbronchial lung cryobiopsy (TBLC) is frequently described for the diagnosis of diffuse parenchymal lung diseases (DPLD). A few studies have reported transbronchial cryobiopsy for the diagnosis of peripheral pulmonary lesions (PPL...s). We aimed to study the utility and safety of transbronchial cryobiopsy for the diagnosis of PPL...s. We performed a systematic search of the PubMed and Embase databases to extract the relevant studies. We then performed a meta-analysis to calculate the diagnostic yields of transbronchial cryobiopsy and bronchoscopic forceps biopsy. Following a systematic search, we identified nine relevant studies (300 patients undergoing cryobiopsy). All used Radial Endobronchial Ultrasound (R-EBUS) for PPL localization. The pooled diagnostic yield of transbronchial cryobiopsy was 77% (95% CI, 71%...84%) (I^2=38.72%, p=0.11). The diagnostic yield of forceps biopsy was 72% (95% CI, 60%...83%) (I^2=78.56%, p
ISSN:2531-0437
2531-0437
DOI:10.1016/j.pulmoe.2020.12.006