Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function

Modulation of endothelial calcium-activated potassium (K ) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of K channels with small (K 2.x) and intermediate (K 3.1) conductance, NS309 and NS4591, improve endothelium-depe...

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Bibliographic Details
Published in:Frontiers in pharmacology 2017-09, Vol.8, p.660-660
Main Authors: Comerma-Steffensen, Simon G, Carvacho, Ingrid, Hedegaard, Elise R, Simonsen, Ulf
Format: Article
Language:English
Subjects:
calcium activated potassium channels
corpus cavernosum
erectile function
KCa2.3
NS309
NS4591
Pharmacology
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Summary:Modulation of endothelial calcium-activated potassium (K ) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of K channels with small (K 2.x) and intermediate (K 3.1) conductance, NS309 and NS4591, improve endothelium-dependent relaxation and erectile function. Rat (CC) strips were mounted for isometric tension recording and processed for immunoblotting. Mean arterial pressure (MAP), intracavernosal pressure (ICP), and electrocardiographic (ECG) measurements were conducted in anesthetized rats. Immunoblotting revealed the presence of K 2.3 and large K conductance (K 1.1) channels in the . NS309 and NS4591 increased current in CC endothelial cells in whole cell patch clamp experiments. Relaxation induced by NS309 (
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2017.00660