Associations between antipsychotics-induced weight gain and brain networks of impulsivity

Given the unpredictable rapid onset and ubiquitous consequences of weight gain induced by antipsychotics, there is a pressing need to get insights into the underlying processes at the brain system level that will allow stratification of “at risk” patients. The pathophysiological hypothesis at hand i...

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Bibliographic Details
Published in:Translational psychiatry 2024-03, Vol.14 (1), p.162-162, Article 162
Main Authors: Grosu, Claire, Klauser, Paul, Dwir, Daniella, Khadimallah, Ines, Alemán-Gómez, Yasser, Laaboub, Nermine, Piras, Marianna, Fournier, Margot, Preisig, Martin, Conus, Philippe, Draganski, Bogdan, Eap, Chin B.
Format: Article
Language:English
Subjects:
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Antipsychotics
Behavioral Sciences
Biological Psychology
Impulsivity
Medicine
Medicine & Public Health
Middle age
Neurosciences
Pharmacotherapy
Psychiatry
Psychosis
Psychotropic drugs
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Summary:Given the unpredictable rapid onset and ubiquitous consequences of weight gain induced by antipsychotics, there is a pressing need to get insights into the underlying processes at the brain system level that will allow stratification of “at risk” patients. The pathophysiological hypothesis at hand is focused on brain networks governing impulsivity that are modulated by neuro-inflammatory processes. To this aim, we investigated brain anatomy and functional connectivity in patients with early psychosis (median age: 23 years, IQR = 21–27) using anthropometric data and magnetic resonance imaging acquired one month to one year after initiation of AP medication. Our analyses included 19 patients with high and rapid weight gain (i.e., ≥5% from baseline weight after one month) and 23 patients with low weight gain (i.e.,
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-024-02881-4