Biocompatible Alginate Hydrogel Film Containing Acetic Acid Manifests Broad-Spectrum Antiviral and Anticancer Activities

Acetic acid, a colourless liquid organic acid with a characteristic acrid smell, is obtained naturally and has applications in both the food and pharmaceutical industries. It has been reported to have beneficial uses for lifestyle-related diseases, and its efficient disinfectant properties are well...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicines 2023-09, Vol.11 (9), p.2549
Main Authors: Cano-Vicent, Alba, Tuñón-Molina, Alberto, Bakshi, Hamid, Alfagih, Iman M, Tambuwala, Murtaza M, Serrano-Aroca, Ángel
Format: Article
Language:English
Subjects:
Acetic acid
Acids
alginate
Alginic acid
anticancer
antiviral
Antiviral activity
Antiviral agents
Bacteria
Calcium alginate
Cancer
Care and treatment
Chloride
Colon cancer
Disinfectants
Epidermal growth factor
Food industry
hydrogel
Hydrogels
Melanoma
Nematodes
Organic acids
Penicillin
Pharmaceutical industry
Severe acute respiratory syndrome coronavirus 2
Toxicity
Vinegar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acetic acid, a colourless liquid organic acid with a characteristic acrid smell, is obtained naturally and has applications in both the food and pharmaceutical industries. It has been reported to have beneficial uses for lifestyle-related diseases, and its efficient disinfectant properties are well known. In this study, an alginate crosslinked with Ca hydrogel film was treated with acetic acid to explore its biological properties for biomedicine. The results showed that the novel calcium alginate/acetic acid film was biocompatible in vitro using human keratinocyte cells and in vivo with . It also had antiviral properties against enveloped and non-enveloped viruses and anticancer properties against melanoma and colon cancer cells. This novel film thus showed promise for the biomedical and pharmaceutical industries, with applications for fabricating broad-spectrum antiviral and anticancer materials.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11092549