Clinical application of serum tumor abnormal protein in prostate cancer patients

• Published in: BMC cancer 2024-05, Vol.24 (1), p.665-7, Article 665
• Main Authors: Fu, Liusong, Zhang, Chi, Wang, Zewen, Tao, Wei, Zhu, Jin, Zhou, Yibin, Sun, Chuanyang, Xue, Boxin, Yu, Mengqi, Xu, Lijun, Zang, Yachen
• Format: Article
• Language: English
• Subjects: Aged; Analysis; Biomarkers, Tumor - blood; Biopsy; Care and treatment; Diagnosis; Humans; Hyperplasia; Male; Medical prognosis; Metastasis; Methods; Middle Aged; Neoplasm Grading; Neoplasm Proteins - blood; Neoplasm Staging; Patients; Prognosis; Prostate; Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - pathology; Reagents; Sensitivity and Specificity; Statistical analysis; Tumor abnormal protein; Tumor marker; Tumor proteins; Tumor staging; Tumors; Ultrasonic imaging
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-024-12418-z

To explore the clinical value of tumor abnormal protein (TAP) in the diagnosis and prognosis evaluation of prostate cancer. This study enrolled a total of 265 patients who underwent prostate biopsy procedures from December 2017. TAP levels were assayed in their blood samples using a validated TAP testing kit. Comprehensive pathological assessments, including Gleason scores, TNM staging, and AJCC prognosis stages, were conducted on prostate cancer patients. Further analysis was carried out to examine the correlation between TAP expression levels and various clinical characteristics. A significantly elevated TAP concentration was discerned in prostate cancer patients relative to those with benign prostate hyperplasia. Moreover, a significantly elevated TAP expression was detected in prostate cancer patients with high Gleason score (≥ 8) and advanced stages (III and IV), as compared to those with Gleason scores of 6 and 7 and lower stages (I and II). When diagnosing prostate cancer in gray area of PSA, TAP demonstrated superior diagnostic capabilities over PSA alone, with higher diagnostic sensitivity, specificity and accuracy than fPSA/tPSA ratio. Additionally, post-surgical or hormonal treatment, there was a marked reduction in TAP expression level among prostate cancer patients. The assessment of TAP presents itself as a promising tool for early diagnosis and holds potential for sensitivity in monitoring treatment reponse in prostate cancer patients.