The application of nanodiscs in membrane protein drug discovery & development and drug delivery

The phospholipid bilayer nanodiscs (LNDs), as a rapidly-developing tool in recent years, provide a natural bio-memebrane environment to maintain the native conformation and functions of membrane proteins as well as a versatile delivery vehicle for a variety of hydrophobic and hydrophilic drugs. We h...

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Bibliographic Details
Published in:Frontiers in chemistry 2024-09, Vol.12, p.1444801
Main Authors: Dong, Yingkui, Tang, Huan, Dai, Han, Zhao, Hongxin, Wang, Junfeng
Format: Article
Language:English
Subjects:
Chemistry
drug delievery
drug discovery & development
membrane protein
membrane scaffold protein (MSP)
nanodisc (ND)
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Summary:The phospholipid bilayer nanodiscs (LNDs), as a rapidly-developing tool in recent years, provide a natural bio-memebrane environment to maintain the native conformation and functions of membrane proteins as well as a versatile delivery vehicle for a variety of hydrophobic and hydrophilic drugs. We have seen unprecedented advantages of phospholipid bilayer nanodiscs in membrane protein structure characterization, biochemical and physiological studies of membrane proteins, membrane environment studies, drug discovery & development, and drug delivery. Many previous reviews have been mainly focused on the advantages of nanodiscs in membrane protein researches, but few have touched upon the importance and potential application of nanodiscs in pharmaceutical industries. This review will provide general description of the structural characteristics, advantages, classification, and applications of phospholipid nanodiscs, with particular focus on nanodisc-enabled membrane protein drug discovery & development as well as drug delivery.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2024.1444801