Langerhans Cell Expression in Oral Submucous Fibrosis: An Immunohistochemical Analysis

Langerhans cells (LCs), are dendritic cells of the epithelium which play a role in an array of oral lesions from gingivitis to oral cancer. Oral Submucous Fibrosis (OSMF), a potentially malignant disorder (PMD), is an insidious chronic disease with juxta-epithelial inflammatory changes leading to fi...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2015-07, Vol.9 (7), p.ZC39-ZC41
Main Authors: Narayanan, Bharghavi, Narasimhan, Malathi
Format: Article
Language:English
Subjects:
cd1a
cell mediated immunity
dendritic cells
Dentistry Section
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Summary:Langerhans cells (LCs), are dendritic cells of the epithelium which play a role in an array of oral lesions from gingivitis to oral cancer. Oral Submucous Fibrosis (OSMF), a potentially malignant disorder (PMD), is an insidious chronic disease with juxta-epithelial inflammatory changes leading to fibrosis. Langerhans cells (LCs) may play a part in the ongoing inflammatory dysregulation of OSMF. The study was aimed at elucidating the distribution of LCs in varying grades of OSMF. A retrospective study using 39 cases of OSMF, graded using Haematoxylin and Eosin (H&E) stained section. Immunohistochemistry was performed using polyclonal anti- CD1a antibodies to identify LCs in 5 cases of normal tissue and 39 samples of OSMF. The distribution of LCs among the various grades and normal mucosa analysed using Mann-Whitney U test. LC population in the OSMF was significantly higher when compared to the normal epithelium (p
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2015/12608.6196