Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease

The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed to overcome this disease. In this review, researchers collected information about dysfunctional energy in neurodegenerative diseases driven by mitochondria. Mitochondrial dysregulation c...

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Bibliographic Details
Published in:Heliyon 2023-07, Vol.9 (7), p.e18123-e18123, Article e18123
Main Authors: Widyarti, Sri, Wibowo, Syahputra, Sabarudin, Akhmad, Abhirama, Intan, Sumitro, Sutiman Bambang
Format: Article
Language:English
Subjects:
Dysfunctional energy
energy
hydrogen peroxide
Low dose H2O2
Mitochondria
Neurodegenerative disease
neurodegenerative diseases
neurons
Review
α-Synuclein
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Summary:The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed to overcome this disease. In this review, researchers collected information about dysfunctional energy in neurodegenerative diseases driven by mitochondria. Mitochondrial dysregulation can cause damage to the neuron system. The increase in the amount and interaction of α-synuclein with SAMM50 and GABARAPL1 in the mitochondria is one of the factors causing neurodegenerative disease. As an energy provider in the body, the existence of harmonization in the regulation of mitochondria, specifically the mitochondrial outer membrane, is important. Low-dose hydrogen peroxide (H2O2) has neuroprotective abilities to overcome the impairment function of mitochondria in neurodegenerative patients. Based on computational simulation of this case, it can be used as a basic concept for the development of the role of H2O2 in neurodegenerative diseases.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e18123