Evaluation of the T-SPOT.TB test, oxidation-related factors, and antimicrobial peptide LL-37 in the diagnosis of pulmonary tuberculosis with type 2 diabetes

Objective To investigate the diagnostic value of the T cell spot (T-SPOT.TB) test, oxidation-related factors (ORF), and antimicrobial peptide LL-37 in patients with pulmonary tuberculosis (PTB) with type 2 diabetes. Methods A total of 560 patients with PTB admitted to our hospital from January 2019...

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Published in:Journal of international medical research 2021-12, Vol.49 (12), p.3000605211064418-3000605211064418
Main Authors: Ma, Liangliang, Chen, Xuelin, Weng, Shengfeng, Yang, Xinting
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antimicrobial Cationic Peptides - analysis
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Humans
Mycobacterium tuberculosis
Peptides
Retrospective Clinical Research Report
Retrospective Studies
Sensitivity and Specificity
Tuberculosis
Tuberculosis, Pulmonary - diagnosis
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Summary:Objective To investigate the diagnostic value of the T cell spot (T-SPOT.TB) test, oxidation-related factors (ORF), and antimicrobial peptide LL-37 in patients with pulmonary tuberculosis (PTB) with type 2 diabetes. Methods A total of 560 patients with PTB admitted to our hospital from January 2019 to April 2021 were retrospectively included in this study. Of these, 232 patients with PTB and type 2 diabetes were assigned to the combined group, and 328 patients without complications were assigned to the PTB group. Results Areas under the curve (AUCs) for the number of spot-forming cells in CFP10 and ESAT-6 test panels detecting PTB with type 2 diabetes were 0.892 (95% confidence interval [CI] 0.831–0.921) and 0.893 (95% CI 0.841–0.935), respectively. CFP10 combined with ESAT-6 had the highest diagnostic value, with sensitivity and specificity levels and an AUC of 87.73%, 88.93%, and 0.942 (95% CI 0.907–0.967), respectively. The levels of total antioxidant capacity, superoxide dismutase, and catalase in the combined group were lower than in PTB and control groups. Conclusion The combination of T-SPOT.TB, ORF, and LL-37 in the diagnosis of pulmonary tuberculosis with type 2 diabetes mellitus has a high diagnostic value and clinical application value.
ISSN:0300-0605
1473-2300
DOI:10.1177/03000605211064418