Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center

Background Intracranial hemorrhage (ICH) is an uncommon but important cause of morbidity and mortality in term neonates. We conducted a retrospective analysis of the clinical characteristics and developmental outcomes of symptomatic ICH in term neonates. Methods A retrospective chart review was cond...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics and neonatology 2010-08, Vol.51 (4), p.208-213
Main Authors: Ou-Yang, Mei-Chen, Huang, Chung-Bin, Huang, Hsin-Chun, Chung, Mei-Yung, Chen, Chih-Cheng, Chen, Feng-Shun, Chao, Pei-Hsin, Chen, I-Lun, Ou-Yang, Mei-Hui, Liu, Chieh-An
Format: Article
Language:English
Subjects:
Age Factors
Biological and medical sciences
Cohort Studies
Critical Care
Female
General aspects
Gestational Age
Hospitalization
Humans
Infant, Newborn
Internal Medicine
intracranial hemorrhage
Intracranial Hemorrhages - diagnosis
Intracranial Hemorrhages - etiology
Intracranial Hemorrhages - therapy
Male
Medical sciences
outcomes
Pediatrics
Retrospective Studies
Risk Factors
term neonates
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Intracranial hemorrhage (ICH) is an uncommon but important cause of morbidity and mortality in term neonates. We conducted a retrospective analysis of the clinical characteristics and developmental outcomes of symptomatic ICH in term neonates. Methods A retrospective chart review was conducted of all term neonates (less than 1 month old) diagnosed with ICH and admitted to the neonatal intensive care unit of Kaohsiung Chang Gung Hospital from December 1991 to December 2008. Demographic characteristics, mode of delivery, laboratory data, clinical presentation, and developmental status were recorded. Results Data for 24 term neonates (17 boys and 7 girls) with a diagnosis of ICH were collected for analysis. The clinical manifestations of ICH included anemia (13/24, 54%), seizure (11/24, 46%), cyanosis (7/24, 29%), tachypnea (5/24, 21%), fever (1/24, 4%), hypothermia (1/24, 4%), and poor feeding (1/24, 4%). Age at symptom onset ranged from 2 hours to 11 days following birth. The most common type of ICH was subdural hemorrhage. All ICHs resolved, except in one infant, who died from hypoxicischemic encephalopathy at 25 days. Ten children with symptomatic ICH were reported to have normal development, while the remainder (13/23, 57%) showed developmental delays or disabilities. Conclusion Unexplained anemia, seizure, and cyanosis were the major presenting signs in infants with symptomatic ICH. A diagnosis of ICH should be considered in term neonates who present with one or more of these signs. Although the mortality in term infants with symptomatic ICH was low, more than half
ISSN:1875-9572
DOI:10.1016/S1875-9572(10)60040-X