Biocompatibility of SU-8 and Its Biomedical Device Applications

SU-8 is an epoxy-based, negative-tone photoresist that has been extensively utilized to fabricate myriads of devices including biomedical devices in the recent years. This paper first reviews the biocompatibility of SU-8 for in vitro and in vivo applications. Surface modification techniques as well...

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Bibliographic Details
Published in:Micromachines (Basel) 2021-07, Vol.12 (7), p.794
Main Authors: Chen, Ziyu, Lee, Jeong-Bong
Format: Article
Language:English
Subjects:
Biocompatibility
Biofouling
biomedical
Biomedical materials
biosensing
Cell culture
Cell growth
Cytotoxicity
Immunosensors
implantable
In vivo methods and tests
Leachates
Materials selection
Mechanical properties
Microelectromechanical systems
Modulus of elasticity
Nervous system
Oxygen plasma
Photoresists
Polymethyl methacrylate
Pressure sensors
Review
Silica
Silicon nitride
SU-8
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Summary:SU-8 is an epoxy-based, negative-tone photoresist that has been extensively utilized to fabricate myriads of devices including biomedical devices in the recent years. This paper first reviews the biocompatibility of SU-8 for in vitro and in vivo applications. Surface modification techniques as well as various biomedical applications based on SU-8 are also discussed. Although SU-8 might not be completely biocompatible, existing surface modification techniques, such as O2 plasma treatment or grafting of biocompatible polymers, might be sufficient to minimize biofouling caused by SU-8. As a result, a great deal of effort has been directed to the development of SU-8-based functional devices for biomedical applications. This review includes biomedical applications such as platforms for cell culture and cell encapsulation, immunosensing, neural probes, and implantable pressure sensors. Proper treatments of SU-8 and slight modification of surfaces have enabled the SU-8 as one of the unique choices of materials in the fabrication of biomedical devices. Due to the versatility of SU-8 and comparative advantages in terms of improved Young’s modulus and yield strength, we believe that SU-8-based biomedical devices would gain wider proliferation among the biomedical community in the future.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi12070794