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Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

ObjectivesWe performed a cross-sectional analysis of data from the nationwide Korea National Health and Nutrition Examination Survey to evaluate the association between obesity and chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyp (CRSsNP).DesignRetrospective cross-sectional a...

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Published in:BMJ open 2021-05, Vol.11 (5), p.e047230-e047230
Main Authors: Nam, Jae-Sung, Roh, Yun Ho, Fahad, Wasan Almazouq, Noh, Hae-Eun, Ha, Jong-Gyun, Yoon, Joo-Heon, Kim, Chang-Hoon, Cho, Hyung-Ju
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description ObjectivesWe performed a cross-sectional analysis of data from the nationwide Korea National Health and Nutrition Examination Survey to evaluate the association between obesity and chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyp (CRSsNP).DesignRetrospective cross-sectional analysis of health survey data.SettingVoluntary survey of representative South Korean populations.ParticipantsIn total, 32 384 individuals aged 19 years or older with available data on CRS and obesity were included.Primary and secondary outcome measuresDiagnosis of CRSwNP or CRSsNP was performed by trained otolaryngologists through sinus endoscopy and surveys of medical history. General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively.MethodsA multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls.ResultsThe prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p
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General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively.MethodsA multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls.ResultsThe prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p&lt;0.001) and central (OR, 1.251; 95% CI, 1.031 to 1.520; p=0.033) obesity groups than in the control group. Prevalence of CRSsNP was not correlated with obesity. In a logistic regression analysis, olfactory dysfunction (OR, 1.329; 95% CI, 1.137 to 1.553; p&lt;0.001) and purulent discharge (OR, 1.383; 95% CI, 1.193 to 1.603; p&lt;0.001) showed a higher incidence in the central obesity group than in the control group.ConclusionsWe demonstrated an association between CRSwNP and general and central obesity. Further investigations on the mechanism underlying this correlation are necessary for an improved understanding of the pathogenesis of CRSwNP.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2020-047230</identifier><identifier>PMID: 34035104</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>adult gastroenterology ; adult otolaryngology ; Body mass index ; Chronic illnesses ; Ear, Nose and Throat/Otolaryngology ; Epidemiology ; Obesity ; Population-based studies ; Rhinitis ; Sinusitis ; Tuberculosis</subject><ispartof>BMJ open, 2021-05, Vol.11 (5), p.e047230-e047230</ispartof><rights>Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b555t-5eb4937597b0b11899c2510fa4df32598e961a8dfe4f2005535496027334df023</citedby><cites>FETCH-LOGICAL-b555t-5eb4937597b0b11899c2510fa4df32598e961a8dfe4f2005535496027334df023</cites><orcidid>0000-0002-2851-3225 ; 0000-0002-3428-8108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2532447356/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2532447356?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>112,113,230,314,727,780,784,885,3194,25753,27549,27550,27924,27925,37012,37013,44590,53791,53793,55341,55350,75126,77594,77595,77596,77597,77601,77632,77660,77686</link.rule.ids></links><search><creatorcontrib>Nam, Jae-Sung</creatorcontrib><creatorcontrib>Roh, Yun Ho</creatorcontrib><creatorcontrib>Fahad, Wasan Almazouq</creatorcontrib><creatorcontrib>Noh, Hae-Eun</creatorcontrib><creatorcontrib>Ha, Jong-Gyun</creatorcontrib><creatorcontrib>Yoon, Joo-Heon</creatorcontrib><creatorcontrib>Kim, Chang-Hoon</creatorcontrib><creatorcontrib>Cho, Hyung-Ju</creatorcontrib><title>Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>ObjectivesWe performed a cross-sectional analysis of data from the nationwide Korea National Health and Nutrition Examination Survey to evaluate the association between obesity and chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyp (CRSsNP).DesignRetrospective cross-sectional analysis of health survey data.SettingVoluntary survey of representative South Korean populations.ParticipantsIn total, 32 384 individuals aged 19 years or older with available data on CRS and obesity were included.Primary and secondary outcome measuresDiagnosis of CRSwNP or CRSsNP was performed by trained otolaryngologists through sinus endoscopy and surveys of medical history. General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively.MethodsA multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls.ResultsThe prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p&lt;0.001) and central (OR, 1.251; 95% CI, 1.031 to 1.520; p=0.033) obesity groups than in the control group. Prevalence of CRSsNP was not correlated with obesity. In a logistic regression analysis, olfactory dysfunction (OR, 1.329; 95% CI, 1.137 to 1.553; p&lt;0.001) and purulent discharge (OR, 1.383; 95% CI, 1.193 to 1.603; p&lt;0.001) showed a higher incidence in the central obesity group than in the control group.ConclusionsWe demonstrated an association between CRSwNP and general and central obesity. Further investigations on the mechanism underlying this correlation are necessary for an improved understanding of the pathogenesis of CRSwNP.</description><subject>adult gastroenterology</subject><subject>adult otolaryngology</subject><subject>Body mass index</subject><subject>Chronic illnesses</subject><subject>Ear, Nose and Throat/Otolaryngology</subject><subject>Epidemiology</subject><subject>Obesity</subject><subject>Population-based studies</subject><subject>Rhinitis</subject><subject>Sinusitis</subject><subject>Tuberculosis</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNUk1r3DAUFKWlCWl-QS6CXnpxoq9nWz0UQmibQKCX5CwkW85q65VcSW7Yf1_tekmaHkoEQnrvzQwjMQidUXJOKa8vzGYdJusrRhipiGgYJ2_QMSNCVDUBePvX_QidprQmZQmQAOw9OuKCcKBEHKOflymFzunsgsfG5kdrPQ7GJpe3WPsed6sYvOtwXDkfkvNzmbiEH11eYa-THvEUxu2UPmNd6p3MvjXN476ojE62xynP_fYDejfoMdnTw3mC7r99vbu6rm5_fL-5urytDADkCqwRkjcgG0MMpa2UHStmBy36gTOQrZU11W0_WDEwUh7IQciasIbzgiCMn6CbRbcPeq2m6DY6blXQTu0bIT4oHbPrRqtEa01jYDBNz0TNwUgqpSRCFzVKqCxaXxataTYb23fW56jHF6IvJ96t1EP4rVpaXDFeBD4dBGL4NduU1calzo6j9jbMSTHgrGwgTYF-_Ae6DnMs_7mghGg41AXFF1QXQ0rRDk9mKFG7bKhDNtQuG2rJRmGdL6wyfCXh4pnw5ON_jD_WL8py</recordid><startdate>20210525</startdate><enddate>20210525</enddate><creator>Nam, Jae-Sung</creator><creator>Roh, Yun Ho</creator><creator>Fahad, Wasan Almazouq</creator><creator>Noh, Hae-Eun</creator><creator>Ha, Jong-Gyun</creator><creator>Yoon, Joo-Heon</creator><creator>Kim, Chang-Hoon</creator><creator>Cho, Hyung-Ju</creator><general>British Medical Journal Publishing Group</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2851-3225</orcidid><orcidid>https://orcid.org/0000-0002-3428-8108</orcidid></search><sort><creationdate>20210525</creationdate><title>Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study</title><author>Nam, Jae-Sung ; 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General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively.MethodsA multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls.ResultsThe prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p&lt;0.001) and central (OR, 1.251; 95% CI, 1.031 to 1.520; p=0.033) obesity groups than in the control group. Prevalence of CRSsNP was not correlated with obesity. In a logistic regression analysis, olfactory dysfunction (OR, 1.329; 95% CI, 1.137 to 1.553; p&lt;0.001) and purulent discharge (OR, 1.383; 95% CI, 1.193 to 1.603; p&lt;0.001) showed a higher incidence in the central obesity group than in the control group.ConclusionsWe demonstrated an association between CRSwNP and general and central obesity. Further investigations on the mechanism underlying this correlation are necessary for an improved understanding of the pathogenesis of CRSwNP.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>34035104</pmid><doi>10.1136/bmjopen-2020-047230</doi><orcidid>https://orcid.org/0000-0002-2851-3225</orcidid><orcidid>https://orcid.org/0000-0002-3428-8108</orcidid><oa>free_for_read</oa></addata></record>
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source BMJ Open Access Journals; Open Access: PubMed Central; BMJ_英国医学会期刊; ProQuest - Publicly Available Content Database
subjects adult gastroenterology
adult otolaryngology
Body mass index
Chronic illnesses
Ear, Nose and Throat/Otolaryngology
Epidemiology
Obesity
Population-based studies
Rhinitis
Sinusitis
Tuberculosis
title Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study
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