The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis

• Published in: Indian heart journal 2019-05, Vol.71 (3), p.199-206
• Main Authors: Fajar, Jonny Karunia, Pikir, Budi Susetio, Sidarta, Erdo Puncak, Berlinda Saka, Putu Nina, Akbar, Rizal Rahmanda, Heriansyah, Teuku
• Format: Article
• Language: English
• Subjects: ACE G2350A; ACE I/D; Angiotensin-converting enzyme; Left ventricular hypertrophy; Review
• ISSN: 0019-4832; 2213-3763
• DOI: 10.1016/j.ihj.2019.07.002

The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. Information related to the sample size and genotype frequencies was extracted from each study. Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy.