Associations of BCL-2 (RS17759659), CTLA-4 (RS231775), APO-1/FAS (RS2234767) genes polymorphisms with activity of proliferation and apoptosis in thyroid tissue of patients with nodular forms of goiter combined with autoimmune thyroiditis and thyroid adenoma

The study of apoptosis and proliferative activity in the thyroid gland (TG) tissue of patients with nodular goiter and autoimmune thyroiditis (NGAIT) and thyroid adenoma (TA) is based on the expression/density of Fas/FasL, BCL-2, p53, and Ki-67 markers assessment depending on the genetic polymorphis...

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Published in:Journal of education, health and sport health and sport, 2017-08, Vol.7 (8)
Main Authors: M. I. Sheremet, L. P. Sydorchuk, V. A. Shidlovskyi, A. D. Bedenyuk, R. I. Sydorchuk, Y. V. Gyrla, O. V. Bilookiy, N. P. Tkachuk, G. S. Kurochkin, A. V. Levitsky
Format: Article
Language:English
Subjects:
APO-1 / FAS
apoptosis
CTLA-4 and BCL-2 genes polymorphisms
nodular goiter with autoimmune thyroiditis
proliferation
thyroid adenoma
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Summary:The study of apoptosis and proliferative activity in the thyroid gland (TG) tissue of patients with nodular goiter and autoimmune thyroiditis (NGAIT) and thyroid adenoma (TA) is based on the expression/density of Fas/FasL, BCL-2, p53, and Ki-67 markers assessment depending on the genetic polymorphisms of BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1/Fas (rs2234767) genes. Several mechanisms of thyroid cells' programmed killing are activated in NGAIT and TA with domination of Fas-induced apoptosis, which strongly associates with the BCL-2 gene's (rs17759659) promoter (F=25.33; p
ISSN:2391-8306