Oxidative Stress and Cocaine Intoxication as Start Points in the Pathology of Cocaine-Induced Cardiotoxicity

Psychomotor stimulants are the most commonly used prohibited substances after cannabis. Globally, their use reaches epidemiological proportions and is one of the most common causes of death in many countries. The use of illicit drugs has negative effects on the cardiovascular system and is one of th...

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Bibliographic Details
Published in:Toxics (Basel) 2021-11, Vol.9 (12), p.317
Main Authors: Georgieva, Ekaterina, Karamalakova, Yanka, Miteva, Radostina, Abrashev, Hristo, Nikolova, Galina
Format: Article
Language:English
Subjects:
Addictive behaviors
Amphetamines
Brain research
Cannabis
Cardiac arrhythmia
Cardiotoxicity
Cardiovascular disease
Cardiovascular system
Catecholamines
Cocaine
Dopamine
Drug abuse
Drug dosages
Epidemiology
Free radicals
Intoxication
Metabolites
Narcotics
Nervous system
nitroxide radicals
Oxidative stress
Pathology
Psychomotor stimulants
Reactive oxygen species
Stimulants
sudden cardiac death
Systematic Review
Toxicity
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Summary:Psychomotor stimulants are the most commonly used prohibited substances after cannabis. Globally, their use reaches epidemiological proportions and is one of the most common causes of death in many countries. The use of illicit drugs has negative effects on the cardiovascular system and is one of the causes of serious cardiovascular pathologies, ranging from abnormal heart rhythms to heart attacks and sudden cardiac death. The reactive oxygen species generation, toxic metabolites formation, and oxidative stress play a significant role in cocaine-induced cardiotoxicity. The aim of the present review is to assess acute and chronic cocaine toxicity by focusing on the published literature regarding oxidative stress levels. Hypothetically, this study can serve as a basis for developing a rapid and effective method for determining oxidative stress levels by monitoring changes in the redox status of patients with cocaine intoxication.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics9120317