Asymptomatic Venous Thromboembolism After Hepatobiliary–Pancreatic Surgery: Early Detection Using D‐dimer and Soluble Fibrin Monomer Complex Levels

Aim The aim was to investigate the usefulness of a preemptive management strategy that includes monitoring serum D‐dimer (DD) and soluble fibrin monomer complex (SFMC) levels for early detection and treatment of venous thromboembolism (VTE) after hepatobiliary–pancreatic (HBP) surgery. Methods Overa...

Full description

Saved in:
Bibliographic Details
Published in:Annals of gastroenterological surgery 2022-01, Vol.6 (1), p.109-118
Main Authors: Hayashi, Hikaru, Shimizu, Akira, Kubota, Koji, Notake, Tsuyoshi, Sugenoya, Shinsuke, Masuo, Hitoshi, Hosoda, Kiyotaka, Yasukawa, Koya, Kobayashi, Ryoichiro, Soejima, Yuji
Format: Article
Language:English
Subjects:
Anticoagulants
Asymptomatic
Bone surgery
Compression therapy
Disease prevention
D‐dimer
hepatobiliary–pancreatic surgery
Laboratories
Original
Patients
prophylactic anticoagulation
soluble fibrin monomer complex
Statistical analysis
Surgical outcomes
Thromboembolism
Thrombosis
Veins & arteries
venous thromboembolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim The aim was to investigate the usefulness of a preemptive management strategy that includes monitoring serum D‐dimer (DD) and soluble fibrin monomer complex (SFMC) levels for early detection and treatment of venous thromboembolism (VTE) after hepatobiliary–pancreatic (HBP) surgery. Methods Overall, 678 patients who underwent HBP surgery between January 2010 and March 2020 were enrolled. Patients with increased postoperative serum DD or SFMC levels underwent contrast‐enhanced computed tomography, and those with VTE received anticoagulant agents. The VTE risk factors were investigated using multivariable analysis. Postoperative changes in DD and SFMC levels were verified, and their ability to identify VTE was evaluated using receiver operating characteristic (ROC) analysis. Results VTE developed in 83 patients (12.2%), and no symptomatic VTE or death due to VTE was observed. Multivariable analysis identified female sex (odds ratio [OR] 2.26; 95% confidence interval [CI] 1.41–3.60; P 
ISSN:2475-0328
2475-0328
DOI:10.1002/ags3.12495