Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review

Carbazoles represent an important class of heterocycles. These have been reported to exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic, antihistaminic, antioxidative, anti-inflammatory, antidiarrhoeal, analgesic, neuroprotective and pancreatic lipase inhibition pr...

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Bibliographic Details
Published in:Molecules 2015-07, Vol.20 (8), p.13496-13517
Main Authors: Bashir, Maryam, Bano, Afifa, Ijaz, Abdul Subhan, Chaudhary, Bashir Ahmad
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - therapeutic use
anticancer
antimicrobial
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Carbazoles - chemistry
Carbazoles - therapeutic use
Humans
N-substituted carbazoles
neuroprotective
Neuroprotective Agents - chemistry
Neuroprotective Agents - therapeutic use
Review
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Summary:Carbazoles represent an important class of heterocycles. These have been reported to exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic, antihistaminic, antioxidative, anti-inflammatory, antidiarrhoeal, analgesic, neuroprotective and pancreatic lipase inhibition properties. A series of carbazole derivatives such as N-substituted carbazoles, benzocarbazoles, furocarbazoles, pyrrolocarbazoles, indolocarbazoles, imidazocarbazoles, etc. have been synthesized. The N-substituted derivatives have gained the attention of researchers due to their therapeutic potential against neurological disorders and cell proliferation. Herein an attempt is made to review the medicinal importance of recently synthesized N-substituted carbazoles.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules200813496