Comparative Effect of ACTH and Related Peptides on Proliferation and Growth of Rat Adrenal Gland

Pro-opiomelanocortin (POMC) is a polypeptide precursor known to yield biologically active peptides related to a range of functions. These active peptides include the adrenocorticotropic hormone (ACTH), which is essential for maintenance of adrenal growth and steroidogenesis, and the alpha-melanocyte...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2016-05, Vol.7, p.39-39
Main Authors: Lotfi, Claudimara Ferini Pacicco, de Mendonca, Pedro O R
Format: Article
Language:English
Subjects:
ACTH
Adrenal Growth
Cell Cycle
Endocrinology
N-POMC
proliferation
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Summary:Pro-opiomelanocortin (POMC) is a polypeptide precursor known to yield biologically active peptides related to a range of functions. These active peptides include the adrenocorticotropic hormone (ACTH), which is essential for maintenance of adrenal growth and steroidogenesis, and the alpha-melanocyte stimulation hormone, which plays a key role in energy homeostasis. However, the role of the highly conserved N-terminal region of POMC peptide fragments has begun to be unraveled only recently. Here, we review the cascade of events involved in regulation of proliferation and growth of murine adrenal cortex triggered by ACTH and other POMC-derived peptides. Key findings regarding signaling pathways and modulation of genes and proteins required for the regulation of adrenal growth are summarized. We have outlined the known mechanisms as well as future challenges for research on the regulation of adrenal proliferation and growth triggered by these peptides.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2016.00039