Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient

Background. Paraneoplastic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary carcinoma is rare. Case Presentation. A 65-year-old man presented with bilateral gynaecomastia with abnormally high levels of β-hCG and elevated oestradiol, progesterone, and testosterone levels...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in oncological medicine 2024-01, Vol.2024, p.8731806-5
Main Authors: Devos, Brecht, Willemse, Cedric, Sterckx, Mira, Debruyne, Johan, Stappaerts, Inge, Van den Mooter, Tom, Hertoghs, Marjan, Abrams, Pascale
Format: Article
Language:English
Subjects:
Alcohol
Biopsy
Cancer therapies
Care and treatment
Case reports
Cell death
Chemotherapy
Choriocarcinoma
Chorionic gonadotropin
Etoposide
Genomics
Glycoproteins
Hormones, Sex
Immunotherapy
Ligands
Lung cancer
Medical prognosis
Metastasis
Mortality
Oncology
Pathology
PET imaging
Proteins
Tomography
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c380t-fce998703ea3bc5521fc8cebe64028327197b1882e4d5f9c38beb5a9af504b0f3
container_end_page 5
container_issue
container_start_page 8731806
container_title Case reports in oncological medicine
container_volume 2024
creator Devos, Brecht
Willemse, Cedric
Sterckx, Mira
Debruyne, Johan
Stappaerts, Inge
Van den Mooter, Tom
Hertoghs, Marjan
Abrams, Pascale
description Background. Paraneoplastic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary carcinoma is rare. Case Presentation. A 65-year-old man presented with bilateral gynaecomastia with abnormally high levels of β-hCG and elevated oestradiol, progesterone, and testosterone levels on April 7, 2023. After excluding testicular malignancy, CT scan of the chest and abdomen revealed bilateral pulmonary lesions. Transthoracic biopsy confirmed malignancy with choriocarcinoma. MRI of the brain showed a solitary brain metastasis, while on a subsequent 18F-FDG PET/CT, no other metastatic lesions were seen. The patient was treated with chemoimmunotherapy carboplatin-etoposide-pembrolizumab with good partial response. Conclusion. Our case of a presumably stage IV dedifferentiated mNSCLC presenting as an extragonadal β-hCG secreting pulmonary choriocarcinoma is a very rare tumor with a poor prognosis. Its biology, origin, and treatment remain to be elucidated. Cancer genome sequencing is necessary for the identification of the origin and seeking treatment.
doi_str_mv 10.1155/2024/8731806
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_493b6cd09e5142fb9e228bba87019228</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A814666339</galeid><doaj_id>oai_doaj_org_article_493b6cd09e5142fb9e228bba87019228</doaj_id><sourcerecordid>A814666339</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-fce998703ea3bc5521fc8cebe64028327197b1882e4d5f9c38beb5a9af504b0f3</originalsourceid><addsrcrecordid>eNp9kV1LHTEQhkNpqaLe9boseNmu5mM3m1zqUj9AqdD2OkyyE83hbKLZPYj_3thzeoogJhcZJs-8M8NLyBdGjxhr22NOeXOsOsEUlR_ILqea1rJjzcdtTOUOOZimBS1Hcilp95nsCCVYw3m3S_pTnKG-6M-rX-gyziHFyj5VUN2slmOKkJ-q_i7lkBxkF2IaoQqxfF_DEqsbmAPGeZ988rCc8GDz7pE_Zz9-9xf11c_zy_7kqnZC0bn2DrVWHRUIwrq25cw75dCibChXgndMd5YpxbEZWq9LkUXbggbf0sZSL_bI5Vp3SLAw9zmMZTyTIJi_iZRvDeQ5uCWaRgsr3UA1tmVRbzVyrqyF0p7pEhatw7XWfU4PK5xms0irHMv4hmvOOi2kYP-p27KuCdGnOYMbw-TMiWKNlFIIXaijN6hyBxyDSxF9KPlXBd_XBS6nacrot8swal58NS--mo2vBf-6mXVlRxy28D8XC_BtDdyFOMBjeF_uGfKlpRI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2921793631</pqid></control><display><type>article</type><title>Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient</title><source>Publicly Available Content Database</source><source>Wiley Open Access</source><source>PubMed Central</source><creator>Devos, Brecht ; Willemse, Cedric ; Sterckx, Mira ; Debruyne, Johan ; Stappaerts, Inge ; Van den Mooter, Tom ; Hertoghs, Marjan ; Abrams, Pascale</creator><contributor>Mayordomo, Jose I. ; Jose I Mayordomo</contributor><creatorcontrib>Devos, Brecht ; Willemse, Cedric ; Sterckx, Mira ; Debruyne, Johan ; Stappaerts, Inge ; Van den Mooter, Tom ; Hertoghs, Marjan ; Abrams, Pascale ; Mayordomo, Jose I. ; Jose I Mayordomo</creatorcontrib><description>Background. Paraneoplastic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary carcinoma is rare. Case Presentation. A 65-year-old man presented with bilateral gynaecomastia with abnormally high levels of β-hCG and elevated oestradiol, progesterone, and testosterone levels on April 7, 2023. After excluding testicular malignancy, CT scan of the chest and abdomen revealed bilateral pulmonary lesions. Transthoracic biopsy confirmed malignancy with choriocarcinoma. MRI of the brain showed a solitary brain metastasis, while on a subsequent 18F-FDG PET/CT, no other metastatic lesions were seen. The patient was treated with chemoimmunotherapy carboplatin-etoposide-pembrolizumab with good partial response. Conclusion. Our case of a presumably stage IV dedifferentiated mNSCLC presenting as an extragonadal β-hCG secreting pulmonary choriocarcinoma is a very rare tumor with a poor prognosis. Its biology, origin, and treatment remain to be elucidated. Cancer genome sequencing is necessary for the identification of the origin and seeking treatment.</description><identifier>ISSN: 2090-6706</identifier><identifier>EISSN: 2090-6714</identifier><identifier>DOI: 10.1155/2024/8731806</identifier><identifier>PMID: 38314227</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Alcohol ; Biopsy ; Cancer therapies ; Care and treatment ; Case reports ; Cell death ; Chemotherapy ; Choriocarcinoma ; Chorionic gonadotropin ; Etoposide ; Genomics ; Glycoproteins ; Hormones, Sex ; Immunotherapy ; Ligands ; Lung cancer ; Medical prognosis ; Metastasis ; Mortality ; Oncology ; Pathology ; PET imaging ; Proteins ; Tomography</subject><ispartof>Case reports in oncological medicine, 2024-01, Vol.2024, p.8731806-5</ispartof><rights>Copyright © 2024 Brecht Devos et al.</rights><rights>COPYRIGHT 2024 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2024 Brecht Devos et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c380t-fce998703ea3bc5521fc8cebe64028327197b1882e4d5f9c38beb5a9af504b0f3</cites><orcidid>0000-0002-9277-4665</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2921793631/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2921793631?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38314227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mayordomo, Jose I.</contributor><contributor>Jose I Mayordomo</contributor><creatorcontrib>Devos, Brecht</creatorcontrib><creatorcontrib>Willemse, Cedric</creatorcontrib><creatorcontrib>Sterckx, Mira</creatorcontrib><creatorcontrib>Debruyne, Johan</creatorcontrib><creatorcontrib>Stappaerts, Inge</creatorcontrib><creatorcontrib>Van den Mooter, Tom</creatorcontrib><creatorcontrib>Hertoghs, Marjan</creatorcontrib><creatorcontrib>Abrams, Pascale</creatorcontrib><title>Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient</title><title>Case reports in oncological medicine</title><addtitle>Case Rep Oncol Med</addtitle><description>Background. Paraneoplastic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary carcinoma is rare. Case Presentation. A 65-year-old man presented with bilateral gynaecomastia with abnormally high levels of β-hCG and elevated oestradiol, progesterone, and testosterone levels on April 7, 2023. After excluding testicular malignancy, CT scan of the chest and abdomen revealed bilateral pulmonary lesions. Transthoracic biopsy confirmed malignancy with choriocarcinoma. MRI of the brain showed a solitary brain metastasis, while on a subsequent 18F-FDG PET/CT, no other metastatic lesions were seen. The patient was treated with chemoimmunotherapy carboplatin-etoposide-pembrolizumab with good partial response. Conclusion. Our case of a presumably stage IV dedifferentiated mNSCLC presenting as an extragonadal β-hCG secreting pulmonary choriocarcinoma is a very rare tumor with a poor prognosis. Its biology, origin, and treatment remain to be elucidated. Cancer genome sequencing is necessary for the identification of the origin and seeking treatment.</description><subject>Alcohol</subject><subject>Biopsy</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Case reports</subject><subject>Cell death</subject><subject>Chemotherapy</subject><subject>Choriocarcinoma</subject><subject>Chorionic gonadotropin</subject><subject>Etoposide</subject><subject>Genomics</subject><subject>Glycoproteins</subject><subject>Hormones, Sex</subject><subject>Immunotherapy</subject><subject>Ligands</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Pathology</subject><subject>PET imaging</subject><subject>Proteins</subject><subject>Tomography</subject><issn>2090-6706</issn><issn>2090-6714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kV1LHTEQhkNpqaLe9boseNmu5mM3m1zqUj9AqdD2OkyyE83hbKLZPYj_3thzeoogJhcZJs-8M8NLyBdGjxhr22NOeXOsOsEUlR_ILqea1rJjzcdtTOUOOZimBS1Hcilp95nsCCVYw3m3S_pTnKG-6M-rX-gyziHFyj5VUN2slmOKkJ-q_i7lkBxkF2IaoQqxfF_DEqsbmAPGeZ988rCc8GDz7pE_Zz9-9xf11c_zy_7kqnZC0bn2DrVWHRUIwrq25cw75dCibChXgndMd5YpxbEZWq9LkUXbggbf0sZSL_bI5Vp3SLAw9zmMZTyTIJi_iZRvDeQ5uCWaRgsr3UA1tmVRbzVyrqyF0p7pEhatw7XWfU4PK5xms0irHMv4hmvOOi2kYP-p27KuCdGnOYMbw-TMiWKNlFIIXaijN6hyBxyDSxF9KPlXBd_XBS6nacrot8swal58NS--mo2vBf-6mXVlRxy28D8XC_BtDdyFOMBjeF_uGfKlpRI</recordid><startdate>20240127</startdate><enddate>20240127</enddate><creator>Devos, Brecht</creator><creator>Willemse, Cedric</creator><creator>Sterckx, Mira</creator><creator>Debruyne, Johan</creator><creator>Stappaerts, Inge</creator><creator>Van den Mooter, Tom</creator><creator>Hertoghs, Marjan</creator><creator>Abrams, Pascale</creator><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9277-4665</orcidid></search><sort><creationdate>20240127</creationdate><title>Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient</title><author>Devos, Brecht ; Willemse, Cedric ; Sterckx, Mira ; Debruyne, Johan ; Stappaerts, Inge ; Van den Mooter, Tom ; Hertoghs, Marjan ; Abrams, Pascale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-fce998703ea3bc5521fc8cebe64028327197b1882e4d5f9c38beb5a9af504b0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alcohol</topic><topic>Biopsy</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Case reports</topic><topic>Cell death</topic><topic>Chemotherapy</topic><topic>Choriocarcinoma</topic><topic>Chorionic gonadotropin</topic><topic>Etoposide</topic><topic>Genomics</topic><topic>Glycoproteins</topic><topic>Hormones, Sex</topic><topic>Immunotherapy</topic><topic>Ligands</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Pathology</topic><topic>PET imaging</topic><topic>Proteins</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devos, Brecht</creatorcontrib><creatorcontrib>Willemse, Cedric</creatorcontrib><creatorcontrib>Sterckx, Mira</creatorcontrib><creatorcontrib>Debruyne, Johan</creatorcontrib><creatorcontrib>Stappaerts, Inge</creatorcontrib><creatorcontrib>Van den Mooter, Tom</creatorcontrib><creatorcontrib>Hertoghs, Marjan</creatorcontrib><creatorcontrib>Abrams, Pascale</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health &amp; Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Directory of Open Access Journals</collection><jtitle>Case reports in oncological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devos, Brecht</au><au>Willemse, Cedric</au><au>Sterckx, Mira</au><au>Debruyne, Johan</au><au>Stappaerts, Inge</au><au>Van den Mooter, Tom</au><au>Hertoghs, Marjan</au><au>Abrams, Pascale</au><au>Mayordomo, Jose I.</au><au>Jose I Mayordomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient</atitle><jtitle>Case reports in oncological medicine</jtitle><addtitle>Case Rep Oncol Med</addtitle><date>2024-01-27</date><risdate>2024</risdate><volume>2024</volume><spage>8731806</spage><epage>5</epage><pages>8731806-5</pages><issn>2090-6706</issn><eissn>2090-6714</eissn><abstract>Background. Paraneoplastic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary carcinoma is rare. Case Presentation. A 65-year-old man presented with bilateral gynaecomastia with abnormally high levels of β-hCG and elevated oestradiol, progesterone, and testosterone levels on April 7, 2023. After excluding testicular malignancy, CT scan of the chest and abdomen revealed bilateral pulmonary lesions. Transthoracic biopsy confirmed malignancy with choriocarcinoma. MRI of the brain showed a solitary brain metastasis, while on a subsequent 18F-FDG PET/CT, no other metastatic lesions were seen. The patient was treated with chemoimmunotherapy carboplatin-etoposide-pembrolizumab with good partial response. Conclusion. Our case of a presumably stage IV dedifferentiated mNSCLC presenting as an extragonadal β-hCG secreting pulmonary choriocarcinoma is a very rare tumor with a poor prognosis. Its biology, origin, and treatment remain to be elucidated. Cancer genome sequencing is necessary for the identification of the origin and seeking treatment.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>38314227</pmid><doi>10.1155/2024/8731806</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9277-4665</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-6706
ispartof Case reports in oncological medicine, 2024-01, Vol.2024, p.8731806-5
issn 2090-6706
2090-6714
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_493b6cd09e5142fb9e228bba87019228
source Publicly Available Content Database; Wiley Open Access; PubMed Central
subjects Alcohol
Biopsy
Cancer therapies
Care and treatment
Case reports
Cell death
Chemotherapy
Choriocarcinoma
Chorionic gonadotropin
Etoposide
Genomics
Glycoproteins
Hormones, Sex
Immunotherapy
Ligands
Lung cancer
Medical prognosis
Metastasis
Mortality
Oncology
Pathology
PET imaging
Proteins
Tomography
title Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A18%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Beta-HCG%20Secretion%20by%20a%20Pulmonary%20Choriocarcinoma%20in%20a%20Male%20Patient&rft.jtitle=Case%20reports%20in%20oncological%20medicine&rft.au=Devos,%20Brecht&rft.date=2024-01-27&rft.volume=2024&rft.spage=8731806&rft.epage=5&rft.pages=8731806-5&rft.issn=2090-6706&rft.eissn=2090-6714&rft_id=info:doi/10.1155/2024/8731806&rft_dat=%3Cgale_doaj_%3EA814666339%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c380t-fce998703ea3bc5521fc8cebe64028327197b1882e4d5f9c38beb5a9af504b0f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2921793631&rft_id=info:pmid/38314227&rft_galeid=A814666339&rfr_iscdi=true